{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:46:33Z","timestamp":1784900793654,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Heliox, a mixture of helium and oxygen, has been shown to improve laminar airflow and decrease airway resistance in children. This study aims to describe the outcomes of heliox use in children with respiratory compromise and to identify variables associated with a need for airway surgical intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of patients who received heliox between 2012 and 2022 at a tertiary care children's hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A hundred and thirty\u2010eight heliox treatments were recorded in 119 children. Twelve patients were excluded. Most (<jats:italic>n<\/jats:italic>\u2009=\u2009100, 84%) patients had significant comorbidities. On average, patients spent a cumulative mean of 94\u2009\u00b1\u2009187\u2009h on heliox therapy per hospital admission. Patients with croup or asthma without known airway pathology presented at an older age than patients with other indications for heliox therapy (4.0\u2009\u00b1\u20094.7 vs. 2.2\u2009\u00b1\u20093.6\u2009years, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) and were significantly less likely to have background diseases (<jats:italic>n<\/jats:italic>\u2009=\u200914, 52% vs. <jats:italic>n<\/jats:italic>\u2009=\u200974, 93%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Overall, 51 (47.7%) patients were recommended tracheostomy placement, airway reconstruction, or palliative care. Cumulative use of heliox for more than 47\u2009h was associated with an increased risk of needing tracheostomy or airway reconstruction (odds ratio 6.2, 95% confidence intervals 2.56\u201314.13, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In multivariable regression analysis, neuromuscular disease, intracranial neuropathology, and cumulative time of heliox were associated with a need for definitive airway intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Heliox may be used as a temporizing agent in children with upper airway obstruction. The effectiveness of heliox use for more than 47\u2009h in children, especially in the presence of neuromuscular disease and intracranial neuropathology should be reconsidered.<\/jats:p><jats:p>Level of evidence: 4.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.70006","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T12:13:13Z","timestamp":1727352793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes of heliox use in children with respiratory compromise: A 10\u2010year single institution experience"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4260-2248","authenticated-orcid":false,"given":"Ashley","family":"Young","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery New York\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Rowland","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Ann and Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"},{"name":"Division of Critical Care Ann and Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0781-8249","authenticated-orcid":false,"given":"Taher","family":"Valika","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"},{"name":"Division of Pediatric Otolaryngology\u2010Head and Neck Surgery Ann and Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saied","family":"Ghadersohi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"},{"name":"Division of Pediatric Otolaryngology\u2010Head and Neck Surgery Ann and Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8816-7141","authenticated-orcid":false,"given":"Inbal","family":"Hazkani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"},{"name":"Division of Pediatric Otolaryngology\u2010Head and Neck Surgery Ann and Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.6.e96"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03006983"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537\u2010200109000\u201000004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246\u2010199103000\u201000013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000154946.62733.94"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727\u201032\u20107724P"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-9-6-739"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(97)70346\u20109"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004\u20102136"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246\u2010199810000\u201000031"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.605"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006822.pub6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(1950)3:1<32::aid\u2010cncr2820030106>3.0.co;2\u20103"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004630\u2010199509000\u201000003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000803"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006565\u2010199702000\u201000010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066604269670"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T12:13:40Z","timestamp":1729858420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.70006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,26]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/lio2.70006"],"URL":"https:\/\/doi.org\/10.1002\/lio2.70006","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,26]]},"assertion":[{"value":"2024-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70006"}}