{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:27:28Z","timestamp":1783121248734,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["22dk0310117h0001"],"award-info":[{"award-number":["22dk0310117h0001"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to clarify the prognosis of asymptomatic endolymphatic hydrops (EH) in healthy volunteers via five\u2010year follow\u2010ups with inner ear magnetic resonance imaging (MRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inner ear MRI was performed on 115 participants recruited as controls in a previous study on Meniere's disease. The endolymphatic space was visualized using Naganawa's method of contrast\u2010enhanced MRI with intravenous gadolinium injection and evaluated using Nakashima's method of 2D imaging analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cochlear or vestibular EH was present in 7.0% of participants (<jats:italic>n<\/jats:italic>\u2009=\u20098), with all cases being unilateral (laterality), moderate (severity), and asymptomatic (onset). Only cochlear\u2010localized EH, only vestibular\u2010localized EH, and both EH were present in 1.7% (<jats:italic>n<\/jats:italic>\u2009=\u20092) (C group), 4.3% (<jats:italic>n<\/jats:italic>\u2009=\u20095) (V group), and 0.9% (<jats:italic>n<\/jats:italic>\u2009=\u20091) (CV group) of participants, respectively. Conducting inner ear MRI after 5\u2009years showed that EH had almost disappeared in two participants in the C and V groups (4\/8, 50.0%). EH was still present in three participants in the V group and one in the CV group (4\/8, 50.0%). One participant in the V group and another in the CV group presented with residual inner ear EH and developed typical symptomatic Meniere's disease (2\/8, 25.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Approximately 7% of healthy participants showed asymptomatic EH. Therefore, EH is not the definitive marker for making a diagnosis of Meniere's disease or the suitable predictor for the development of Meniere's disease. Among these participants, 25% maintained EH and subsequently developed typical Meniere's disease within the next 5\u2009years. Schellong\u2010positive participants maintained persistent EH in the inner ear, and participants with higher scores on the self\u2010rating depression scale developed Meniere's symptoms after 5\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>2a<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.70026","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T11:50:55Z","timestamp":1730980255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognosis of asymptomatic endolymphatic hydrops in healthy volunteers: A five\u2010year cohort study"],"prefix":"10.1002","volume":"9","author":[{"given":"Takahiro","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Nara Medical University  Nara 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