{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:53:21Z","timestamp":1782867201256,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770978"],"award-info":[{"award-number":["81770978"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Sinonasal inverted papilloma (SNIP) has a risk of malignant transformation into SNIP with squamous cell carcinoma (SNIP\u2010SCC). Early detection of SNIP\u2010SCC is crucial for patient outcomes. This study aimed to evaluate the utility of tumor\u2010related hematological indices in the early diagnosis of SNIP\u2010SCC and to develop a nomogram incorporating imaging and clinical features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 159 patients with SNIP with (<jats:italic>n<\/jats:italic>\u2009=\u200934) or without (<jats:italic>n<\/jats:italic>\u2009=\u2009125) SCC. Univariate and multivariate logistic regression analyses were employed to identify independent risk factors and develop nomogram. The diagnostic model was evaluated using receiver operating characteristics (ROC), standard, clinical decision, and clinical impact curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Elevated serum cytokeratin fragment antigen 21\u20101 (CYFRA 21\u20101), the loss of convoluted cerebriform pattern, bone destruction, headache\/facial pain, and epistaxis\/blood\u2010tinged mucus were identified as independent risk factors for SNIP\u2010SCC. The optimal cut\u2010off value for serum CYFRA 21\u20101 was 3.51\u2009ng\/mL, with the nomogram area under the ROC curve of 0.966 based on the above indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings suggest that CYFRA 21\u20101 is a promising diagnostic marker for SNIP\u2010SCC. The nomogram incorporating serum CYFRA 21\u20101, imaging features, and clinical factors demonstrates strong clinical utility and can be a reference tool for clinical decision\u2010making.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.70075","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T12:35:26Z","timestamp":1738845326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of a Clinical Prediction Model to Predict Malignant Transformation of Sinonasal Inverted Papilloma Based on Hematological Indices and Clinical Features"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2006-2835","authenticated-orcid":false,"given":"Kai","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery The Affiliated Hospital of Qingdao University  Qingdao 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