{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:59:16Z","timestamp":1753869556347,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Ultrasound (US) is a well\u2010established imaging modality for the evaluation of head and neck anatomy. The Butterfly iQ is a handheld ultrasound device that uses a semiconductor silicon chip array (capacitive micromachined ultrasound transducers, CMUT) instead of piezoelectric crystals used by traditional ultrasounds (TUS), but its accuracy has not been investigated with respect to salivary gland imaging and associated transcutaneous procedures. We aimed to perform a pilot cadaver study to determine the utility and fidelity of the CMUT\u2010US for parotid and submandibular gland imaging and guiding transcutaneous gland injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One otolaryngologist injected 0.5\u2009mL of dye into three distinct salivary gland sites (two intraparotid sites and one submandibular gland site) bilaterally on 20 cadavers (<jats:italic>n<\/jats:italic>\u2009=\u2009120 glands), using either CMUT\u2010US or TUS to guide injection. The cadavers were dissected to identify whether the dye was accurately injected into each site.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The accuracies of CMUT\u2010US and TUS\u2010guided injections in the parotid gland were 95.0% (<jats:italic>n<\/jats:italic>\u2009=\u200940) and 90.0% (<jats:italic>n<\/jats:italic>\u2009=\u200940), respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.69). In the submandibular gland, the accuracies for the CMUT\u2010US (<jats:italic>n<\/jats:italic>\u2009=\u200920) and TUS (<jats:italic>n<\/jats:italic>\u2009=\u200920) were both 75.0% (<jats:italic>p<\/jats:italic>\u2009=\u20090.72). Across all salivary gland sites, injection accuracy was 88.3% (<jats:italic>n<\/jats:italic>\u2009=\u200960) using TUS versus 85.0% (<jats:italic>n<\/jats:italic>\u2009=\u200960) using CMUT\u2010US (<jats:italic>p<\/jats:italic>\u2009=\u20090.79). No significant differences between modalities were seen in the accuracy of injection based on injection subsite, laterality, cadaver sex, or age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This pilot study demonstrates that CMUT\u2010US\u2010guided salivary gland injection offers similar high accuracy and reproducibility to TUS\u2010guided injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>V.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.70102","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T12:49:18Z","timestamp":1739882958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound\u2010On\u2010Chip With Semiconductor Silicon Chip Array for Transcutaneous Salivary Gland Injections: A Pilot Cadaver Study"],"prefix":"10.1002","volume":"10","author":[{"given":"David Y.","family":"Goldrich","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Penn State College of Medicine  Hershey Pennsylvania USA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Penn State Milton S Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivam","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao Y.","family":"Sciscent","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanel W.","family":"Eberly","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head 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