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Secondary study objectives are to determine the effect of aspirin on VS growth, hearing function, serum biomarker levels, and the quality of life, as well as to determine the tolerability of aspirin treatment and whether serum biomarker and salicylate levels predict the response to aspirin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Six academic and private medical centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Review of recent English literature regarding prophylactic aspirin use for VS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The retrospective reviews on the utility of aspirin to prevent VS growth are inconclusive. Eighty\u2010four patients have been enrolled in a prospective double\u2010blinded, placebo\u2010controlled trial thus far to determine the effect of aspirin on VS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Completion of a robust study design is necessary. The current aspirin dose has been well tolerated, with minimal adverse events to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Review of retrospective studies: Level 4; Proposed randomized, placebo\u2010controlled, double\u2010blinded clinical trial: Level 2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.70121","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T16:24:43Z","timestamp":1743611083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Why Consider Aspirin for the Treatment of Vestibular Schwannoma? 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