{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:59:17Z","timestamp":1753869557511,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007212","name":"V\u00e4stra G\u00f6talandsregionen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to analyze whether patients with SARS\u2010CoV\u20102 who received surgical tracheotomy had a lower incidence of postoperative bleeding if their LMWH was postponed or canceled on the day of surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with SARS\u2010CoV\u20102 admitted to the intensive care units who underwent surgical tracheotomy were assessed retrospectively through their medical records. Data on comorbidity, LMWH dose, and timing were collected. Bleedings &lt; 72\u2009h post surgery were noted as stomal or airway bleedings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 101 patients included were on LMWH. Twenty\u2010two patients had no change of dose of LMWH, 24 patients had their dose of LMWH postponed to post surgery, and 50 patients had their dose reduced to only the evening dose on the day of surgery. Twenty\u2010six patients had a stomal bleeding, one patient had an airway bleeding, and four patients had both stomal and airway bleedings. No significant difference in the incidence of bleeding was identified between various groups of different LMWH doses or timing, reduced dose versus no change of dose, OR 1.29 (95% CI 0.42\u20133.92). Postponed dose versus no change of dose of LMWH, OR 1.03 (95% CI 0.28\u20133.75). Increasing age was correlated to a higher risk of bleeding post\u2010surgery by an OR of 1.64 (95% CI 1.06\u20132.54, <jats:italic>p<\/jats:italic>\u2009=\u20090.026 for every 10\u2009years added). No fatal bleeding related to surgical tracheotomy was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Decreased doses of LMWH on the day of surgery were not associated with a risk reduction for post\u2010surgical bleeding in patients with SARS\u2010CoV\u20102 who received tracheotomy. Increasing age was a risk factor for post\u2010surgical bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Retrospective, level 3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.70122","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T10:09:58Z","timestamp":1743761398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low Molecular Weight Heparin Dosing in Relation to Postoperative Bleeding After Tracheotomy in Patients Infected With <scp>SARS<\/scp>\u2010<scp>CoV<\/scp>\u20102\u2014A Descriptive Study"],"prefix":"10.1002","volume":"10","author":[{"given":"David","family":"Victorin","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Region V\u00e4stra G\u00f6taland, S\u00f6dra \u00c4lvsborg Hospital  Bor\u00e5s Sweden"},{"name":"Department of Research, Education and Innovation Region V\u00e4stra G\u00f6taland, S\u00f6dra \u00c4lvsborg Hospital  Bor\u00e5s Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Bergquist","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Otorhinolaryngology Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Hafsten","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa","family":"Nihl\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Region V\u00e4stra G\u00f6taland, S\u00f6dra \u00c4lvsborg Hospital  Bor\u00e5s Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2168-3088","authenticated-orcid":false,"given":"Ellen","family":"Lindell","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Region V\u00e4stra G\u00f6taland, S\u00f6dra \u00c4lvsborg Hospital  Bor\u00e5s Sweden"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"157","article-title":"WHO Declares COVID\u201019 a Pandemic","volume":"91","author":"Cucinotta D.","year":"2020","journal-title":"Acta Biomed"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29669"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.34266"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.2.9707046"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28734"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.05.018"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.04.041"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.05.039"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.047430"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14817"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/ACPJ202112210-134"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-04005-0"},{"key":"e_1_2_8_15_1","article-title":"Tracheotomy Earlier Than Recommended Among Patients With Covid\u201019","volume":"118","author":"Nihl\u00e9n \u00c5.","year":"2021","journal-title":"L\u00e4kartidningen"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.560"},{"key":"e_1_2_8_17_1","unstructured":"Infektionsl\u00e4karf\u00f6reningen S \u201cNationellt v\u00e5rdprogram f\u00f6r misst\u00e4nkt och bekr\u00e4ftad covid\u201019 \u201d(2022) https:\/\/infektion.net\/nationellt\u2010vardprogram\u2010covid19\/."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0134"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X221101025"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2022.07.032"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01825-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvab070"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T07:45:35Z","timestamp":1746776735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.70122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/lio2.70122"],"URL":"https:\/\/doi.org\/10.1002\/lio2.70122","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"type":"print","value":"2378-8038"},{"type":"electronic","value":"2378-8038"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70122"}}