{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:57:07Z","timestamp":1789678627248,"version":"4.0.1"},"reference-count":69,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This systematic review aimed to determine the clinical utility of various physical exam findings in the diagnosis of obstructive sleep apnea (OSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review of English articles identified from PubMed, Embase, CENTRAL, and Web of Science databases. Search terms included \u201csleep apnea,\u201d \u201cphysical exam,\u201d \u201cpolysomnography,\u201d and all relevant synonyms. Two reviewers independently screened abstracts, reviewed full texts, and extracted data from all studies that presented associations between physical characteristics and apnea\u2010hypopnea index (AHI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 35 studies representing 13,854 patients were included in this review. The mean difference between high AHI and low AHI groups was 4.09\u2009kg\/m<jats:sup>2<\/jats:sup> (95% CI: 2.78\u20135.39) for BMI, 7.93\u2009cm (3.59\u201312.28) for waist circumference, and 3.67\u2009cm (2.64\u20134.71) for neck circumference. The odds ratios for having a high AHI were 2.44 (1.07\u20135.55) for macroglossia, 2.23 (1.68\u20132.96) for Mallampati &gt;\u20092, 1.88 (1.67\u20132.11) for tonsil grade &gt;\u20092, 3.99 (1.94\u20138.21) for pharyngeal grade &gt;\u20092, and 1.57 (1.48\u20131.67) for enlarged uvula. Thyromental distance, retrognathia, Friedman grade, septal deviation, and enlarged turbinates were also assessed and were not found to be statistically significant between AHI groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Several physical exams have strong evidence in the literature supporting their strength at differentiating patients with and without OSA. These should be used routinely among providers who treat OSA, regardless of specialty, to help guide decisions about recommending a sleep study and selecting appropriate treatment. Other physical characteristics may be better assessed through advanced exam techniques or require more research and standardization in the way they are assessed by practitioners.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.70154","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:20:07Z","timestamp":1747228807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Obstructive Sleep Apnea Physical Exam: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2472-7126","authenticated-orcid":false,"given":"Nihal","family":"Punjabi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Loma Linda University Health  Loma Linda California USA"},{"name":"Case Western Reserve\u2014School of Medicine  Cleveland Ohio 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