{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:32:06Z","timestamp":1792661526332,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Basic science studies have shown that essential oils have antibacterial and anti\u2010inflammatory effects in the nasal mucosa. However, clinical studies examining the effect of essential oils on patient outcomes are limited. The aim of this systematic review is to evaluate the patient outcomes following treatment of acute rhinosinusitis with essential oils.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Ovid, Cochrane, and Embase computerized searches were performed to include results published up to December 2023. Two independent reviewers (C.M.M. and W.J.) conducted data extraction following a predetermined protocol, with any discrepancies reviewed by the senior author (J.C.W.).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five RCTs investigated the treatment of rhinosinusitis with essential oils in capsule form. Essential oils included in the studies were Cineole, Myrtol (ELOM\u2010080), Sinupret (BNO 1016), and Tavipec. Significant improvements in rhinological symptoms were seen in Cinole compared to placebo, Cinole compared to an herbal compound similar in composition to Sinupret, Tavipec compared to placebo, and ELOM\u2010080 compared to placebo. Outcome measures included nasal obstruction, nasal drainage, facial pressure, headache, fatigue, and fever. Little difference in patient\u2010reported rhinological symptom improvement was seen in ELOM\u2010080 compared to BNO 1016 using a 5\u2010point Likert Scale. Minimal adverse effects were observed in patients treated with essential oils with the most common adverse effect being mild gastrointestinal upset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients using essential oils reported improvement in acute rhinosinusitis symptoms in all studies reviewed, despite differences in methodology and outcome measures. These improvements were statistically significant in all the studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level 1 based on \u201cThe Oxford 2011 Levels of Evidence\u201d.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70189","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T01:09:30Z","timestamp":1750900170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Essential Oils in the Treatment of Acute Rhinosinusitis: A Systematic Review"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9366-7346","authenticated-orcid":false,"given":"Christina M.","family":"Matl","sequence":"first","affiliation":[{"name":"Texas Tech University Health Sciences Center School of Medicine  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooyoung","family":"Jang","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center School of Medicine  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan R.","family":"Salley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Texas Southwestern Medical School  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-8173","authenticated-orcid":false,"given":"Callie L.","family":"Fort","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center School of Medicine  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Demke","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Texas Tech University Health Sciences Center  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phat","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences Texas Tech University Health Sciences Center  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.600"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3355"},{"key":"e_1_2_9_4_1","first-page":"1","article-title":"Summary Health Statistics for U.S. Adults: National Health Interview Survey, 2012","volume":"10","author":"Blackwell D. 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