{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:28:05Z","timestamp":1778596085000,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113\u20102314\u2010B418\u2010004"],"award-info":[{"award-number":["NSTC 113\u20102314\u2010B418\u2010004"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In the era of Hydrops MRI, a clinical dilemma has emerged: while Meniere's disease (MD) is diagnosed unilaterally, Hydrops MRI demonstrates endolymphatic hydrops (EH) bilaterally. This study aims to clarify this ongoing discrepancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010six MD patients underwent an inner ear test battery followed by 3\u2009T Hydrops MRI. Eight unilateral MD patients with EH on both ears were classified as Group A and subdivided into Groups A1 (symptomatic EH on the affected ear, <jats:italic>n<\/jats:italic>\u2009=\u20098 ears) and A2 (asymptomatic EH on the opposite unaffected ear, <jats:italic>n<\/jats:italic>\u2009=\u20098 ears). Another 48 unilateral MD patients with EH on one ear only were referred to Group B and were subdivided into Group B1 (present EH, <jats:italic>n<\/jats:italic>\u2009=\u200948 ears) and Group B2 (absent EH, <jats:italic>n<\/jats:italic>\u2009=\u200948 ears).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both Groups A1 and B1 showed a significantly declining sequence of abnormality rates running from audiometry, cervical, and ocular vestibular\u2010evoked myogenic potential tests to caloric test. However, such a declining trend was not observed in Groups A2 and B2. Significant differences in the abnormality rates of audiometry were noted in Groups A1 (88%) versus A2 (0) and Groups B1 (94%) versus B2 (27%). Four (50%) out of eight ears in Group A2 progressed to MD after a mean interval of 4\u2009\u00b1\u20092\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>If Hydrops MRI identifies EH in both ears of a unilateral MD patient, monitoring cochlear symptoms, hearing thresholds, and imaging findings in the opposite (unaffected) ear may help predict the progression from unilateral MD to bilateral MD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.70216","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T12:19:08Z","timestamp":1753964348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ongoing Discrepancy Between Unilateral Meniere's Disease and Bilateral Endolymphatic Hydrops on Hydrops <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"10","author":[{"given":"Ting\u2010Hua","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling\u2010Chen","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3194-5811","authenticated-orcid":false,"given":"Yi\u2010Ho","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Far Eastern Memorial Hospital  New Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894830920S501"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199303000-00007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000216815.75512.03"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2019.1632482"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2021.1934537"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.2012-0027"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-150549"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/19160216241250350"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.14109"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.869"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23640"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3856"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-019-02155-7"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000312199"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309139425"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948909801108"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-09012-1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600418"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.70026"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.28"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2014.962184"}],"container-title":["Laryngoscope 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