{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:35:07Z","timestamp":1787636107873,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Frailty is a predictor of poor outcomes following surgery for malignancy. Our study investigates the association between the modified 5\u2010item frailty index (mFI\u20105) and postoperative outcomes following parotidectomy for malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional database study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>National Surgical Quality Improvement Program (NSQIP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The 2005\u20132018 NSQIP was retrospectively queried for patients undergoing parotidectomy for malignancy. Cases were stratified by the modified 5\u2010item frailty index (mFI\u20105), which was calculated by the presence of 5 comorbidities: hypertension requiring medication, diabetes mellitus, congestive heart failure in the last 30\u2009days, lung pathology, and functional health status. Univariate and multivariate analyses were performed to identify associations between mFI\u20105 and demographic, comorbid, and complication variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 14,567 patients were identified and stratified by the mFI\u20105. Univariate analysis showed an increasing incidence of American Society of Anesthesiologists (ASA) class, all comorbidities, and all complications with increasing mFI\u20105 score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariable regressions showed increased odds of any surgical complication in patients with mFI\u20105\u2009\u2265\u20092 compared with mFI\u20105\u2009=\u20090 (aOR 2.56; 95% CI: 1.37\u20134.76,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011), as well as increased odds of unplanned readmission (aOR 4.02; 95% CI: 1.16\u201313.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032) and reoperation (aOR 6.61; 95% CI: 1.07\u201340.68,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The mFI\u20105 is associated with increased incidence of comorbidities and complications, as well as increased odds of surgical complications, unplanned readmission, and reoperation in patients undergoing parotidectomy for malignancy, independent of age and ASA class. The mFI\u20105 can be utilized in the risk stratification of these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70220","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T07:49:44Z","timestamp":1757749784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modified 5\u2010Item Frailty Index and Postoperative Outcomes Following Parotidectomy for Malignancy"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-6418","authenticated-orcid":false,"given":"Ariana L.","family":"Shaari","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshav","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0794-041X","authenticated-orcid":false,"given":"Aman M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cowan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-5862","authenticated-orcid":false,"given":"Andrey","family":"Filimonov","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghayoour S.","family":"Mir","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.21209"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194\u20105998(99)70323\u20102"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2020.08.026"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010008\u20100882\u20107"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"135","article-title":"Clinical Approach and Treatment of Benign and Malignant Parotid Masses, Personal Experience","volume":"31","author":"Bussu F.","year":"2011","journal-title":"Acta Otorhinolaryngologica Italica"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.08.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.12.168"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31924"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27951"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.107045"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.935"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100044\u20101788540"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2024.1854"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211010443"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2022.12.014"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.181"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000002088"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818825466"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28222"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.4202"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.0707"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2024.06.148"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X211037257"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.537"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.476"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2021.08.009"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010023\u201004461\u2010w"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26735"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010021\u201003841\u20104"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31446"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29485"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24790"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029\u2010023\u201002944\u20103"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003276"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894211041222"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.667"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28587"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.13166"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103121"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2022.04.004"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.0412"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481908500826"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.14051"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.3969"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17653"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100043\u20101770908"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.4513"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijc.IJC_503_17"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1368\u20108375(02)00007\u20106"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2021.07.027"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.01.021"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2003.50020"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u201011\u201065"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.0670"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)61460\u20104"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1072\u20107515(98)00195\u20101"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03339806"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/28.4.363"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2017.11.005"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:54:52Z","timestamp":1761663292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.70220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,13]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/lio2.70220"],"URL":"https:\/\/doi.org\/10.1002\/lio2.70220","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,13]]},"assertion":[{"value":"2025-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70220"}}