{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:04:59Z","timestamp":1791644699366,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Injection augmentation (or injection laryngoplasty) is a common treatment for presbyphonia. As current injection materials are temporary, it is anticipated that patients injected for presbyphonia will either need a repeat injection or framework surgery to maintain glottal competence (or sufficient glottal closure). Despite the expected temporary nature of these injections, patients report variable durability of effect, and some do not require a repeat injection. The primary aim of this investigation was to identify factors that affect treatment durability of injection augmentation among patients with presbyphonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent one or multiple injection augmentations for presbyphonia between May 2008 and September 2017 were extracted from the UW Madison Voice and Swallow Outcomes Database. Variables collected included demographics (age, sex), injection material, volume, duration between injections, date of first and last follow\u2010up, voice therapy (yes\/no, number of sessions), and pre\u2010 and post\u2010injection voice measures (Maximum Phonation Time, Dysphonia Severity Index, Glottal Function Index score, Vocal Handicap Index Score) in an observational cohort design. For patients receiving one injection (TF group), duration between injection and last follow\u2010up was taken as a durability measure termed \u201ctime to follow up.\u201d For patients receiving multiple injections (TR group), duration between injection treatments were termed \u201ctime to reinjection.\u201d Patients receiving one or more injections were compared separately and together (where treatment durability<jats:sub>TF+TR<\/jats:sub> refers to the combined TF\u2009+\u2009TR group) in different statistical analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five patients with presbyphonia met inclusion criteria (mean age 74.3\u2009years [SD 7.6], 78% male). Twenty patients received only one injection. Repeat injection augmentation was performed in 40% of patients (<jats:italic>n<\/jats:italic>\u2009=\u200915, ranging from 1 to 6 additional injection augmentations). Maximum phonation time increased after injection augmentation (or injection laryngoplasty) and was similar across injection materials (HA (mean change (SD)): +6\u2009s (3) [95% CI 0.1\u20130.8], CaHa: +4\u2009s (2.8) [95% CI 0.2\u20130.7], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Treatment durability<jats:sub>TF+TR<\/jats:sub> was longer for hyaluronic acid injectables when compared to calcium hydroxyapatite injectables (1232\u2009days [CI: 552\u20131911] vs. 257\u2009days [168\u2013345], <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>(2)\u2009=\u20097.505, <jats:italic>p<\/jats:italic>\u2009=\u20090.023). Voice therapy extended treatment durability TF<jats:sub>+TR<\/jats:sub> for injection augmentation compared to no voice therapy (1388 [95% CI: 772\u20132003] vs. 277\u2009days [206\u2013349\u2009days], <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>(1)\u2009=\u20099.173, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). Age did not affect treatment durability TF<jats:sub>+TR<\/jats:sub> (<jats:italic>\u03c7<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>(1)\u2009<jats:italic>=<\/jats:italic>\u20091.01, <jats:italic>p<\/jats:italic>\u2009=\u20090.67).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Factors that affected treatment durability TF<jats:sub>+TR<\/jats:sub> for injection augmentation treatments were the type of injectable and whether patients underwent adjuvant voice therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>III, Retrospective cohort study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.70223","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:25:17Z","timestamp":1754486717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment Durability of Injection Augmentation of Vocal Fold Atrophy"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4341-9701","authenticated-orcid":false,"given":"Anumitha","family":"Venkatraman","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery University of Wisconsin Madison  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9592-932X","authenticated-orcid":false,"given":"Ruth J.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery University of Wisconsin Madison  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-4356","authenticated-orcid":false,"given":"Susan","family":"Thibeault","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery University of Wisconsin Madison  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999\u2010018\u20100095\u20106"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.0409"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2022.09.019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2015.12.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112417"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420931556"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103353"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010022\u201007437\u20100"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2019.03.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000540"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2017.68868"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40136\u2010014\u20100038\u20109"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2020.08.040"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2011.04.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2020.12.017"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.11.961"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360.0603.66"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7064"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2021.09.006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420952464"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20890"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2012.750034"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2011.11.007"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2022.03.017"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2023.01.020"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211045292"}],"container-title":["Laryngoscope 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