{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:52:49Z","timestamp":1776095569311,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate tolerance to office\u2010based laser surgery (OBLS) in patients with no prior history of mental illnesses, and to analyze the correlation between patient tolerance, anxiety, and depression using validated questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients aged 18\u201365 with no prior history of mental disorders undergoing OBLS from May 2024 to September 2024 were included in this study. All patients completed the Generalized Anxiety Disorder scale\u20107 (GAD\u20107) and the Patient Health Questionnaire\u20109 (PHQ\u20109). After surgery, tolerance was assessed using the IOWA satisfaction with anesthesia scale and a Visual Analog Scale for discomfort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 25 patients were enrolled. Eighteen patients had moderate\u2013severe anxiety and six patients had moderate\u2013severe depression. The mean GAD\u20107 was 12.32\u2009\u00b1\u20094.09, and the PHQ\u20109 score was 6.60\u2009\u00b1\u20095.43. The mean IOWA score was 1.78\u2009\u00b1\u20091.07, and the mean VAS for discomfort was 4.60\u2009\u00b1\u20093.31. There was a moderate negative correlation between IOWA score and GAD\u20107 score (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.489) and a mild positive correlation between the GAD\u20107 score and the VAS score for discomfort (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.372). A mild negative correlation was found between IOWA scores and PHQ\u20109 scores (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.357) and a weak positive correlation between the PHQ\u20109 score and the VAS score (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.204). It is important to note that although this study group had a high risk for anxiety and depression, the results indicated that OBLS was a well\u2010tolerated procedure. This could be ascribed to the non\u2010invasiveness of OBLS and proper application of topical anesthesia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study revealed a high tolerance level despite a high risk for anxiety and depression in a large percentage of our study group. Moreover, there was a mild to moderate negative correlation between anxiety, depression, and patient tolerance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70256","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T13:19:44Z","timestamp":1758115184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Correlation Between Anxiety, Depression, and Patient Tolerance in Patients With no Prior History of Mental Disorders Undergoing Office\u2010Based Laser Surgery: A Case Study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-3568","authenticated-orcid":false,"given":"Abdul\u2010Latif","family":"Hamdan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana","family":"Ghzayel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeina Maria","family":"Semaan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar Aboul","family":"Hosn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Marie","family":"Daou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan Abou","family":"Chaar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader","family":"Nawfal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine American University of Beirut  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5227-6215","authenticated-orcid":false,"given":"Randa","family":"Barazi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery American University of Beirut Medical Center  Beirut 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