{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:07:51Z","timestamp":1761664071747,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Prior studies investigating the impacts of social determinants of health (SDoH) on hypopharyngeal cancer have only assessed the impact of individual factors on patient outcomes. This study uses the CDC's Social Vulnerability Index (SVI) and a national patient cohort to examine how the interrelational influence of SDoH affect hypopharyngeal cancer prognosis, treatment, and follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analyzed patients from 1975 to 2017 with a diagnosis of hypopharyngeal carcinoma in the NCI\u2010SEER database. Net social vulnerability and its contributions from 15 SDoH variables were ranked and scored across all US counties, yielding a SVI. SVI scores were matched to the patient's county of residence, and univariate linear regressions were performed on the length of care and prognosis, while univariate logistic regressions were performed on advanced staging at presentation and treatment modalities across SVI quintiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Across 16,038 hypopharyngeal cancer patients, there was a significant 22.3% (35.41\u201327.50\u2009months) decrease in survival time and a 16.6% (40.00\u201333.36\u2009months) decrease in surveillance time between the lowest and highest overall\u2010social vulnerability groups. Patients with greater vulnerability were more likely to have advanced staging at presentation and to receive chemotherapy, but less likely to receive surgery or radiation, with each treatment being differentially associated with vulnerability factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study on SDoH in adults with hypopharyngeal carcinoma found significant declines in care and prognosis with higher social vulnerability, along with specific associations across SDoH themes, underscoring the need for targeted public health interventions to mitigate these disparities and improve cancer care equity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70260","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:43:55Z","timestamp":1761392635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Social Vulnerability Associations With Hypopharyngeal Carcinoma Treatment and Prognostic Disparities"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2528-4148","authenticated-orcid":false,"given":"Camaren M.","family":"Cuenca","sequence":"first","affiliation":[{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Bruss","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, College of Medicine University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4485-8274","authenticated-orcid":false,"given":"David J.","family":"Fei\u2010Zhang","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill N.","family":"D'Souza","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Division of Pediatric Otolaryngology, Louisiana State University Health Sciences Center, Children's Hospital of New Orleans  New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5924-3689","authenticated-orcid":false,"given":"Anthony M.","family":"Sheyn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Otolaryngology Le Bonheur Children's Hospital  Memphis Tennessee USA"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Department of Pediatric Otolaryngology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0168-549X","authenticated-orcid":false,"given":"Jeffrey C.","family":"Rastatter","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Northwestern University Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Division of Pediatric Otolaryngology Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel C.","family":"Chelius","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Pediatric Thyroid Tumor Program and Pediatric Head and Neck Tumor Program, Baylor College of Medicine, Texas Children's Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/LARY.24651"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/IJC.20740"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0B013E318173DC4A"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/028418698430467"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAOTO.2024.1180"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAOTO.2021.3425"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/CANCERS15061781"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0282603"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/HED.27492"},{"key":"e_1_2_9_11_1","unstructured":"Agency for Toxic Substances and Disease Registry \u201cCDC SVI Documentation 2018 \u201dhttps:\/\/www.atsdr.cdc.gov\/placeandhealth\/svi\/documentation\/SVI_documentation_2018.html."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JDIN.2024.05.011"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JDIN.2024.07.025"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALR.23334"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/OHN.675"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/S10434\u2010024\u201015038\u2010W"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/HED.27783"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/JNCIMONOGRAPHS\/LGU020"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10147\u2010020\u201001671\u20104"},{"volume-title":"Summary of State Law Requirements Addressing Language Needs in Health Care","year":"2019","author":"Youdelman M.","key":"e_1_2_9_20_1"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11606\u2010007\u20100366\u20102"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/HEALTHCARE12030364\/S1"},{"volume-title":"Medicare Program; Hospital Inpatient Prospective Payment Systems for Acute Care Hospitals and the Long\u2010Term Care Hospital Prospective Payment System and Policy Changes and Fiscal Year 2023 Rates; Quality Programs and Medicare Promoting Interoperability Program Requirements for Eligible Hospitals and Critical Access Hospitals; Costs Incurred for Qualified and Non\u2010Qualified Deferred Compensation Plans; and Changes to Hospital and Critical Access Hospital Conditions of Participation","year":"2022","author":"Department of Health and Human Services, Centers for Medicare & Medicaid Services","key":"e_1_2_9_23_1"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAOTO.2024.1181"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/JNS.2023.111"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:54:19Z","timestamp":1761663259000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.70260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/lio2.70260"],"URL":"https:\/\/doi.org\/10.1002\/lio2.70260","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"type":"print","value":"2378-8038"},{"type":"electronic","value":"2378-8038"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70260"}}