{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:09:24Z","timestamp":1761664164505,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between cardiovascular health, measured by Life's Essential 8 (LE8) score, and hearing loss and tinnitus among U.S. adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional analysis was conducted on 4624 adults (\u2265\u200920\u2009years) from NHANES 2005\u20132018\u2009cycles. Cardiovascular health was assessed via the LE8 score, encompassing eight health behaviors and factors. Audiometry\u2010measured speech\u2010frequency hearing loss, defined as pure\u2010tone average (PTA) \u2265\u200920\u2009dB in the better ear at 500\u20134000\u2009Hz, and subjective hearing loss and tinnitus were assessed using self\u2010reported questionnaires. Multivariable logistic regression models adjusted for confounders examined associations between LE8 scores and auditory conditions. Additional analyses included restricted cubic spline regression, subgroup, and sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher LE8 scores, indicating better cardiovascular health, were significantly associated with lower odds of audiometry\u2010measured speech\u2010frequency hearing loss (adjusted OR: 0.84; 95% CI: 0.77\u20130.92), subjective hearing loss (adjusted OR: 0.82; 95% CI: 0.77\u20130.88), and tinnitus (adjusted OR: 0.88; 95% CI: 0.81\u20130.96). Subgroup analyses showed consistent associations for audiometry\u2010measured hearing loss and tinnitus across demographic strata, while findings for subjective hearing loss varied by sex. Sensitivity analyses confirmed the robustness of the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Better cardiovascular health, as measured by LE8 score, is associated with lower odds of hearing loss and tinnitus among U.S. adults. These findings suggest that the LE8 score may serve as a valuable integrated metric for evaluating cardiovascular health in relation to auditory outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>2b.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70270","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:35:36Z","timestamp":1760106936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Life's Essential 8 With Hearing Loss and Tinnitus in\n                    <scp>U.S.<\/scp>\n                    Adults"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4195-2887","authenticated-orcid":false,"given":"Xing","family":"Lin","sequence":"first","affiliation":[{"name":"Department of 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Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"Fujian Institute of Otorhinolaryngology, the First Affiliated Hospital Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3078-2851","authenticated-orcid":false,"given":"Heng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"Department of Otolaryngology Head and Neck Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"Fujian Institute of Otorhinolaryngology, the First Affiliated Hospital Fujian Medical University  Fuzhou 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