{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T04:07:03Z","timestamp":1774152423042,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Olfactory dysfunction significantly impairs quality of life. Conventional treatments such as corticosteroids and olfactory training offer limited and inconsistent efficacy. Platelet\u2010rich plasma (PRP), a biologically active agent, has shown potential regenerative effects in olfactory neuroepithelium. This study systematically evaluates the efficacy of PRP compared to placebo in improving olfactory function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis was conducted according to PRISMA guidelines and was registered in\u00a0PROSPERO (CRD 420251045079). The databases searched included PubMed, Scopus, Embase, Central, and Web of\u00a0Science.\u00a0Seven studies (four RCTs, three non\u2010RCTs) involving 789 patients were included. Subjective and objective outcomes were extracted and pooled using a random\u2010effects model. Risk of bias was assessed using ROB\u20102 and ROBIN\u2010I tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PRP was significantly more effective than placebo in improving subjective olfactory scores at 1\u2009month (SMD\u2009=\u20091.16, 95% CI [0.29\u20132.03],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009), 3\u2009months (SMD\u2009=\u20090.29, 95% CI [0.07\u20130.50],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), and 12\u2009months (SMD\u2009=\u20091.47, 95% CI [1.06\u20131.89],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.00001). Objective testing also favored PRP at all timepoints, including 1\u2009month (SMD\u2009=\u20091.55, 95% CI [0.36\u20132.73],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), 3\u2009months (SMD\u2009=\u20090.44, 95% CI [0.05\u20130.82],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), and 12\u2009months (SMD\u2009=\u20092.42, 95% CI [0.35\u20134.5],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Subgroup analysis showed younger age (&lt;\u200940\u2009years old) was associated with greater improvements. The safety profile was favorable with no serious adverse events reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PRP demonstrates both short\u2010 and long\u2010term benefits in olfactory recovery compared to placebo, especially among younger adults. Given the promising results and safety profile, PRP represents a viable treatment option for olfactory dysfunction. Standardization of PRP protocols and further high\u2010quality RCTs need to be further explored.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70317","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T06:01:18Z","timestamp":1765864878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Platelet Rich Plasma Versus Placebo for Improvement in Olfactory Function in Adults With Olfactory Dysfunction: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7666-8010","authenticated-orcid":false,"given":"Ali B.","family":"Jafar","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine, Health Sciences Center Kuwait University  Kuwait City Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghabrielle","family":"Almeida","sequence":"additional","affiliation":[{"name":"Florida State University College of Medicine  Tallahassee Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Al Mousawi","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Health Sciences Center Kuwait University  Kuwait City Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2522-4408","authenticated-orcid":false,"given":"Eric Delgado","family":"Rendon","sequence":"additional","affiliation":[{"name":"Florida State University College of Medicine  Tallahassee Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6078-8010","authenticated-orcid":false,"given":"Amber U.","family":"Luong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University of Texas Health Science Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892420946254"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.18.2307"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjv057"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx081"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjt072"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-020-01751-5"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.12.049"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24447"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr165"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20100775"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102889"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-069503"},{"key":"e_1_2_12_14_1","article-title":"Management of Post\u2010Infectious Anosmia and Hyposmia: A Systematic Review","volume":"132","author":"Nag A. 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