{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:08:18Z","timestamp":1792789698494,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the ancestral background of patients with idiopathic subglottic stenosis (iSGS) using genetic testing results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A de\u2010identified survey collecting genetic testing service ancestry data results, in addition to self\u2010reported ancestry, personal autoimmune history, and any family history of iSGS, was distributed to members of the Facebook group \u201cLiving with Idiopathic Subglottic Stenosis.\u201d Exclusion criteria included age\u2009&lt;\u200918, non\u2010idiopathic stenosis or ANCA\u2010positive antibody status, and supraglottic or tracheobronchial location of stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1242 participants (99.4% female) met inclusion criteria, with 62.4% residing in the US. Genetic testing service results were available in 377 patients, in which European ancestry was most reported (86.6%), specifically Northwestern Europe. By country, ancestry within the United Kingdom, Ireland, and Germany were most common (56%, 40%, and 39%, respectively), all of which are reported at an increased rate when comparing to the US Census. Self\u2010reported ancestry results displayed similar patterns (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.44). Autoimmune history was self\u2010reported in 170 patients (13.6%), and family history of iSGS was present in 5.0%; neither varied based on ancestry. Twenty\u2010four patients overall (1.9%) had predominantly non\u2010Caucasian\/non\u2010European ancestry: 2.2% of the self\u2010reported cohort and 1.3% of the testing service result cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A cohort of primarily North American patients with iSGS report higher rates of ancestry from Northwestern Europe than the US population at large. These findings support potential genetic contributions to disease development. Additionally, as a subset of patients were identified as non\u2010Caucasian within our cohort, further characterization of this \u201catypical\u201d patient population should be performed to determine whether patients may be underdiagnosed worldwide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70349","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:11:28Z","timestamp":1770718288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Northwestern European Ancestry Predominates in Idiopathic Subglottic Stenosis: Results From an English\u2010Speaking Cohort"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-9031","authenticated-orcid":false,"given":"Jarod","family":"Karom","sequence":"first","affiliation":[{"name":"The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly O.","family":"Hunter","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Anderson","sequence":"additional","affiliation":[{"name":"Independent Researcher  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7717-9423","authenticated-orcid":false,"given":"Zachary Thomas","family":"Root","sequence":"additional","affiliation":[{"name":"University of Illinois College of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9558-5202","authenticated-orcid":false,"given":"Laura A.","family":"Matrka","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery The Ohio State University Wexner Medical Center  Columbus Ohio 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