{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:43:41Z","timestamp":1790628221492,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n \n We evaluated the impact of teprotumumab therapy (\n TT<\/jats:styled-content>\n ) introduction on orbital decompression (\n OD<\/jats:styled-content>\n ) utilization for thyroid eye disease (\n TED<\/jats:styled-content>\n ) and compared rates of significant exophthalmos reduction (\n SER<\/jats:styled-content>\n ) and diplopia between\n TT<\/jats:styled-content>\n and\n OD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Newly diagnosed\n TED<\/jats:styled-content>\n patients treated pre (2015\u20132020) and post teprotumumab (2020\u20132025)\n FDA<\/jats:styled-content>\n approval were identified from the\n EHR<\/jats:styled-content>\n . Utilization trends, diplopia rates, and immediate (\u2264\u20096\u2009weeks post\u2010intervention) and long\u2010term follow\u2010up\n SER<\/jats:styled-content>\n (\u2265\u20092\u2009mm reduction) were studied.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 406\n TED<\/jats:styled-content>\n patients, 53 (36.8%) underwent\n OD<\/jats:styled-content>\n in the pre\u2010\n TT<\/jats:styled-content>\n cohort (\n n<\/jats:italic>\n \u2009=\u2009144). Post\u2010teprotumumab approval (\n n<\/jats:italic>\n \u2009=\u2009262), primary\n OD<\/jats:styled-content>\n was performed in 29 (11.1%), of which 3 (10.3%) were subsequently placed on\n TT<\/jats:styled-content>\n ; primary\n TT<\/jats:styled-content>\n was used in 68\/262 (25.9%) with subsequent\n OD<\/jats:styled-content>\n performed in 9 (13.2%). The remaining patients used other treatments (corticosteroids, orbital radiation, rituximab, tocilizumab, etc.). In the overall cohort, immediate SER was achieved in 94.4% of OD versus 83.8% of TT patients (\n p<\/jats:italic>\n \u2009=\u20090.028), with greater median reduction in the OD group (5 vs. 4\u2009mm;\n p<\/jats:italic>\n \u2009=\u20090.001). At long\u2010term follow\u2010up (median 13 vs. 12\u2009months), SER was sustained in 85.4% of OD and 62.9% of TT patients (\n p<\/jats:italic>\n \u2009=\u20090.042). Pre\u2010therapy diplopia was more prevalent in TT vs. OD patients (79.4% vs. 59.7%;\n p<\/jats:italic>\n \u2009=\u20090.019). New\u2010onset posttreatment diplopia was higher in the OD group (20.7% vs. 5.9%;\n p<\/jats:italic>\n \u2009=\u20090.008).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Rates of\n OD<\/jats:styled-content>\n surgery declined following\n FDA<\/jats:styled-content>\n approval of teprotumumab.\n OD<\/jats:styled-content>\n achieved sustained and greater exophthalmos reduction but carried a higher risk of diplopia. Contemporaneous\n OD<\/jats:styled-content>\n indications may have evolved to use in TT\u2010recalcitrant\n TED<\/jats:styled-content>\n or those in need of urgent decompression.\n <\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 4.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lio2.70351","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:08:56Z","timestamp":1770718136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Teprotumumab for Thyroid Eye Disease: Efficacy and Impact on Orbital Decompression Utilization"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9923-9254","authenticated-orcid":false,"given":"Nitish","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head & Neck Surgery Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6422-5271","authenticated-orcid":false,"given":"Pedro","family":"Lan\u00e7a Gomes","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head & Neck Surgery Mayo Clinic Phoenix Arizona USA"},{"name":"Postgraduate Program in Medical Sciences Universidade de Bras\u00edlia Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Jategaonkar","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine\u2010Arizona Campus Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-0310","authenticated-orcid":false,"given":"Michael J.","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head & Neck Surgery Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Miglani","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head & Neck Surgery Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-2385","authenticated-orcid":false,"given":"Devyani","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head & Neck Surgery Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0625-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-11-0006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0596"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.050807"},{"key":"e_1_2_9_6_1","article-title":"Graves' Eye Disease: Clinical and Radiological Diagnosis","volume":"11","author":"Hutchings K. R.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0666"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae526"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab824"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2024.06.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23603"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.73.8.639"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910434"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000002531"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae052"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000002611"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511538"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad637"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01593-z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-024-02967-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001949"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(25)00066-X"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.2331047.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12222"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/01676830.2023.2282509"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.70351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:51:04Z","timestamp":1772970664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.70351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/lio2.70351"],"URL":"https:\/\/doi.org\/10.1002\/lio2.70351","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70351"}}