{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:01:12Z","timestamp":1772989272199,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To implement a multidisciplinary anaplastic thyroid cancer rapid response team (ARRT) pathway in a universal healthcare system and evaluate its impact on diagnostic and treatment timelines for patients with anaplastic thyroid cancer (ATC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This quasi\u2010experimental study was conducted at a tertiary care cancer center in Canada. We compared 26 consecutive adult patients with confirmed ATC: 11 patients in the pre\u2010pathway period (January 2015\u2013June 2020) and 15 in the post\u2010pathway period (July 2020\u2013July 2023). The ARRT pathway incorporated early identification of suspected cases, image\u2010guided biopsies with rapid on\u2010site cytology evaluation, expedited staging and molecular analysis, coordinated same\u2010day multidisciplinary consultations, and early palliative care involvement. Outcomes included time from initial clinical suspicion to staging completion, multidisciplinary assessment, and treatment initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ARRT pathway significantly reduced median time from initial suspicion to staging completion from 21\u2009days (IQR: 12\u201345) to 6\u2009days (IQR: 2\u20139) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), time to multidisciplinary assessment from 28\u2009days (IQR: 14\u201371) to 8\u2009days (IQR: 6\u201314) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), and time to treatment initiation from 29\u2009days (IQR: 18\u201383) to 18\u2009days (IQR: 14\u201321) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035). Post\u2010pathway patients demonstrated greater consistency in rapid molecular testing (100% vs. 54%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and higher rates of R0\/R1 resection (4\/4 patients [100%] vs. 1\/6 patients [17%],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The ARRT pathway reduced diagnostic and treatment delays for ATC patients within a universal healthcare system. This rapid response model demonstrates feasibility and effectiveness in improving care coordination for rare aggressive malignancies. The approach provides a replicable four\u2010phase implementation framework for similar healthcare systems globally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70360","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T04:01:18Z","timestamp":1771214478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Implementing a Rapid Response Pathway for Anaplastic Thyroid Cancer in a Universal Healthcare System"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7257-1473","authenticated-orcid":false,"given":"Sana","family":"Ghaznavi","sequence":"first","affiliation":[{"name":"Department of Medicine, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Oncology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Ohlson Research Initiative, Arnie Charbonneau Cancer Institute, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiana","family":"Mahboubi","sequence":"additional","affiliation":[{"name":"Ohlson Research Initiative, Arnie Charbonneau Cancer Institute, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Surgery, Division of Otolaryngology\u2010Head and Neck Surgery, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie","family":"Lamb","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara","family":"Hawker","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-4351","authenticated-orcid":false,"given":"Khara","family":"Sauro","sequence":"additional","affiliation":[{"name":"Ohlson Research Initiative, Arnie Charbonneau Cancer Institute, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"O'Brien Institute of Public Health, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Douglas","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Ohlson Research Initiative, Arnie Charbonneau Cancer Institute, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Surgery, Division of Otolaryngology\u2010Head and Neck Surgery, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean","family":"Ruether","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Box","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moosa","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Gorombey","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Dort","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Surgery, Division of Otolaryngology\u2010Head and Neck Surgery, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamir","family":"Chandarana","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Ohlson Research Initiative, Arnie Charbonneau Cancer Institute, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Surgery, Division of Otolaryngology\u2010Head and Neck Surgery, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0944"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2010.03.013"},{"key":"e_1_2_10_4_1","first-page":"873","volume-title":"AJCC Cancer Staging Manual","author":"Tuttle R. 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