{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:53:20Z","timestamp":1781877200182,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25lk022119"],"award-info":[{"award-number":["JP25lk022119"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n We aimed to evaluate the long\u2010term auditory outcomes of early antiviral therapy with valganciclovir (VGCV) in children with congenital cytomegalovirus (cCMV) infection, regardless of initial symptomatology.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This retrospective cohort study included 56 pediatric patients (112 ears) diagnosed with cCMV infection between 2004 and 2022 at our institution. The participants were divided into those who received (treated group,\n n<\/jats:italic>\n \u2009=\u200919) and did not receive (untreated group,\n n<\/jats:italic>\n \u2009=\u200937) VGCV or ganciclovir therapy. Audiological assessments were conducted over a minimum 2\u2010year follow\u2010up period (range, 2\u201315\u2009years). Furthermore, hearing thresholds were evaluated longitudinally, with a decline of \u2265\u200910\u2009dB being defined as significant. The primary outcomes were hearing loss progression and age at onset.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At the final follow\u2010up, there were no significant between\u2010group differences in the prevalence or severity of hearing loss. However, fewer ears showed significant hearing deterioration in the treated group (26%) than in the untreated group (41%,\n p<\/jats:italic>\n \u2009<\u20090.01). Furthermore, the magnitude of hearing decline was smaller in the treated group (35.0\u2009\u00b1\u200913.8\u2009dB) than in the untreated group (67.4\u2009\u00b1\u200919.2\u2009dB) (\n p<\/jats:italic>\n \u2009<\u20090.002). Hearing loss in treated patients stabilized by the age of 3\u2009years; in contrast, untreated patients experienced multiple deterioration episodes even after this age.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Early VGCV treatment may help stabilize hearing and reduce long\u2010term hearing deterioration in children with cCMV infections. This highlights the importance of early intervention and hearing surveillance, especially in untreated individuals.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 4<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lio2.70386","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T01:46:52Z","timestamp":1774921612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Outcomes in Children With Congenital Cytomegalovirus Infection"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7231-1658","authenticated-orcid":false,"given":"Noriko","family":"Morimoto","sequence":"first","affiliation":[{"name":"Department of Otolaryngology National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriomi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Saikawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050700"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(03)00192-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.12.027"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11133582"},{"issue":"25","key":"e_1_2_10_6_1","first-page":"2463","article-title":"Valganciclovir for Congenital Cytomegalovirus","volume":"372","author":"Kimberlin D. W.","year":"2015","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.670"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.02.026"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2024.113934"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2024.113945"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2025.105778"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piab095"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-022-04691-6"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70386","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.70386","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:11:35Z","timestamp":1781874695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.70386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/lio2.70386"],"URL":"https:\/\/doi.org\/10.1002\/lio2.70386","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]},"assertion":[{"value":"2025-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70386"}}