{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:53:20Z","timestamp":1781877200225,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective(s)<\/jats:title>\n                    <jats:p>Assess the analgesic and potential adverse effects of gabapentinoids in patients undergoing upper airway surgery (UAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis was conducted following PRISMA guidelines. Data sources included Ovid Medline, Embase, Scopus, and Cochrane. All RCTs and cohort studies from June 2002 to August 2024 regarding treatment outcomes of gabapentinoids for UAS were extracted. Studies were subjected to a two\u2010reviewer blinded screening, extraction, and appraisal process. Assessment of study quality was implemented via the NIH quality assessment tool for RCTs. Primary outcome was decreased postoperative pain. Secondary outcomes included adverse drug events and opiate needs postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 397 studies screened, 21 met inclusion criteria. There were 828 gabapentinoid patients and 684 controls. Twelve studies were adenotonsillectomies and tonsillectomies, six were septoplasties, one was septoplasty with and without turbinoplasty, one lateral pharyngoplasty and tonsillectomy, and one maxillomandibular advancement. Appraisal revealed studies were of low (18) and moderate (3) risk of bias. Meta\u2010analyses with subgroupings as appropriate were performed for these categories: pain score at 0\u20132 and 16\u201324\u2009h; opioid consumption post\u2010surgery; minutes to first analgesia; postoperative dizziness, nausea, and vomiting. Gabapentinoids significantly lowered pain levels 0\u20132 and 16\u201324\u2009h postoperatively, decreased opioid consumption, and increased time to first analgesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review of current scientific literature supports perioperative use of gabapentinoids for UAS to reduce postoperative pain and lower analgesic requirement. Future studies should include larger cohorts with standardized protocols regarding timing, dosing of medication, objective measurements, proper blinding procedures for study personnel, and robust statistical analysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70390","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:50:37Z","timestamp":1776851437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gabapentinoids for Upper Airway Surgery Pain Management: Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8517-7013","authenticated-orcid":false,"given":"Andrew Stephen","family":"Franklin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad Alexander","family":"Nieri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Washington University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7231-4231","authenticated-orcid":false,"given":"Meghana Chowdhary","family":"Chanamolu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex Leonardo","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenessa","family":"McElfresh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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