{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:53:20Z","timestamp":1781877200088,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K00440"],"award-info":[{"award-number":["JP24K00440"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25K20871"],"award-info":[{"award-number":["JP25K20871"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the time\u2010dependent changes in olfactory threshold and identification ability during olfactory rehabilitation in patients who had undergone laryngectomy and to investigate the recovery process for different odor types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nineteen patients who underwent laryngectomy participated in olfactory rehabilitation using the nasal airflow\u2010inducing maneuver (NAIM). Olfactory function was assessed at baseline and at 1, 3, 6, and 12\u2009months post\u2010NAIM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 19 participants, 12 (63.1%) continued the program for 6\u2009months, whereas 8 (42.1%) completed the 12\u2010month assessment. The mean olfactory threshold improved from 2.7 at baseline to \u22121.5 at 12\u2009months, reaching normal levels by 1\u2009month. The recognition threshold (identification ability) improved from 4.1 at baseline to \u22120.3 at 12\u2009months, with significant recovery observed by 3\u2009months. Odor\u2010specific recovery patterns varied: Isovaleric acid showed improvement at 1\u2009month; methyl cyclopentenolone, \u03b3\u2010undecalactone, and skatole at 3\u2009months; and \u03b2\u2010phenylethyl alcohol at 6\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients who underwent laryngectomy, the olfactory thresholds recovered earlier than the identification abilities. The rate of recovery differed among odor types, with more rapid improvement observed for odors of physiological importance, such as putrid smells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4 Laryngoscope, 2024.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70406","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:40:24Z","timestamp":1776217224000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Changes in Olfactory Threshold During Rehabilitation After Total Laryngectomy: A Preliminary Study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-7254","authenticated-orcid":false,"given":"Yumi","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Umezaki","sequence":"additional","affiliation":[{"name":"International University of Health and Welfare Graduate School  Fukuoka Japan"},{"name":"Department of ENT Voice &amp; Swallowing Center, Fukuoka Sanno Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Murakami","sequence":"additional","affiliation":[{"name":"Speech Therapy Course, Department of Allied Health Sciences Kitasato University  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of ENT Voice &amp; Swallowing Center, Fukuoka Sanno Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Sawatsubashi","sequence":"additional","affiliation":[{"name":"Home Medical Care Services Beppu Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mioko","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/S2179\u201064912011000100017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010003\u20100638\u20103"},{"key":"e_1_2_9_4_1","first-page":"5","article-title":"The Human Nasal Mucosa After Deprivation of Airflow: A Study of Laryngectomy Patients","volume":"30","author":"Fisher E. 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