{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:53:37Z","timestamp":1781877217910,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1S10OD032192"],"award-info":[{"award-number":["1S10OD032192"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000104","name":"National Aeronautics and Space Administration","doi-asserted-by":"publisher","award":["80NSSC23M0205"],"award-info":[{"award-number":["80NSSC23M0205"]}],"id":[{"id":"10.13039\/100000104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate how subperichondrial mobilization affects implant\u2010tissue mechanics, glottal configuration, and vibratory behavior in computational simulations of medialization laryngoplasty (ML).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used a finite\u2010discrete element method (FDEM) framework to simulate subperichondrial tissue\u2010cartilage separation and implant insertion in laryngeal models reconstructed from high\u2010resolution magnetic resonance imaging. Four dissection conditions were evaluated, ranging from no mobilization to increasing dissection length distal to the thyroplasty window. Outcome measures included change in glottal area, vocal fold medial displacement, finite element fracturing along the tissue\u2010cartilage interface, and estimated vibratory frequency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Increasing dissection length produced increased medial displacement, progressive reductions in glottal area, fewer secondary extensions of the dissection plane during implantation, and higher estimated vibratory frequencies (range: 100.4\u2013120.8\u2009Hz). These findings indicate that subperichondrial tissue mobilization alters implant\u2010induced force transmission and modifies boundary conditions relevant to vibration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this first application of FDEM to simulate laryngeal biomechanics in ML, subperichondrial dissection length demonstrated direct effects on model predictions relevant to implant sizing, placement strategy, and anticipated phonatory outcomes. Incorporating tissue mobilization into computational frameworks as a mechanically meaningful variable improves physiological realism and supports future development of subject\u2010specific surgical planning tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level V. This study provides preclinical computational evidence using FDEM, supporting and extending clinical observations in ML.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70419","type":"journal-article","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T03:39:44Z","timestamp":1777174784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive Numerical and Experimental Investigations on Endolaryngeal Mobilization"],"prefix":"10.1002","volume":"11","author":[{"given":"Weibing","family":"Cai","sequence":"first","affiliation":[{"name":"Morgan State University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azure","family":"Wilson","sequence":"additional","affiliation":[{"name":"Morgan State University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofeng","family":"He","sequence":"additional","affiliation":[{"name":"Morgan State University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Hary","sequence":"additional","affiliation":[{"name":"University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Tkac","sequence":"additional","affiliation":[{"name":"University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9000-6323","authenticated-orcid":false,"given":"Stephanie","family":"Misono","sequence":"additional","affiliation":[{"name":"University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Sayce","sequence":"additional","affiliation":[{"name":"University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0132-8812","authenticated-orcid":false,"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"Morgan State University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/01455613231176153"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010021\u201007177\u20107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5106\/jjshns.25.373"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/app9112288"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.616985"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.34172\/bi.2023.23809"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2017.00007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810700711"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25267"},{"key":"e_1_2_10_11_1","first-page":"2273","volume-title":"Interspeech","author":"Reddy N.","year":"2022"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2011.00019"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4064662"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/app11041817"},{"key":"e_1_2_10_15_1","unstructured":"A.Munjiza \u201cDiscrete Elements in Transient Dynamics of Fractured Media \u201d(1992) https:\/\/www.croris.hr\/crosbi\/publikacija\/ocjenski\u2010rad\/425796."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470020180"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010023\u201003250\u2010w"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13451"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.015"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00603\u2010024\u201003789\u20107"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201088147\u20105"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.29596"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2013.05.010"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.70419","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:12:56Z","timestamp":1781874776000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.70419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/lio2.70419"],"URL":"https:\/\/doi.org\/10.1002\/lio2.70419","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70419"}}