{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:40:43Z","timestamp":1787841643632,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This scoping review evaluates the current literature on tumor growth rate in head and neck cancer patients and its potential prognostic value on survival, loco\u2010regional control and recurrence (PROSPERO registration CRD42022370828).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, and Scopus were searched for publications between 1990 and November 5th 2025. Studies providing measures of treatment\u2010na\u00efve HNSCC tumor growth, estimated from tumor volume derived from two pre\u2010therapeutic scans and\/or related outcome evaluations, were included. The risk of bias was assessed using the QUIPS tool. Data analysis was summarized in tables and reported following the PRISMA\u2010ScR recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen papers met the inclusion criteria. Among them, eight provided an actual growth rate, and nine conducted a statistical analysis of survival outcomes. There was significant heterogeneity in study design, imaging technique, volume measurement, growth rate calculation, confounding factors, and prognostic impact. Overall, despite some studies suggesting a correlation between tumor kinetics and survival and loco\u2010regional control, there is insufficient data to conduct a proper meta\u2010analysis or to confirm tumor growth rate as a valid predictor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tumor kinetics could influence treatment planning and therapy for HNSCC patients in a more personalized way. However, even though some authors have shown a significant impact of Tumor\u2010specific growth rate (TSGR) on survival and loco\u2010regional control, important heterogeneity across articles on this topic fails to yield consistent results, making it difficult to achieve good risk stratification. Recommendations for future research were summarized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>NA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70458","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:41:19Z","timestamp":1782888079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumor Growth Rate in Head and Neck Squamous Cell Carcinoma: A Scoping Review"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4336-4192","authenticated-orcid":false,"given":"Gilles","family":"Delahaut","sequence":"first","affiliation":[{"name":"ENT and Head &amp; Neck Surgery Department CHU UCL Namur site de Godinne  Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Jamme","sequence":"additional","affiliation":[{"name":"Cervico\u2010facial carcinology department Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Krug","sequence":"additional","affiliation":[{"name":"Nuclear Medicine department CHU UCL Namur site de Godinne  Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Daisne","sequence":"additional","affiliation":[{"name":"Oncologisch Centrum Antwerpen, Iridium Netwerk\u2010ZAS Augustinus  Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Hassid","sequence":"additional","affiliation":[{"name":"ENT and Head &amp; Neck Surgery Department CHU UCL Namur site de Godinne  Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Van der 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