{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:40:25Z","timestamp":1787841625797,"version":"build-2784847793"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["TMU113\u2010AE1\u2010B04"],"award-info":[{"award-number":["TMU113\u2010AE1\u2010B04"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Chronic rhinitis (CR) may be allergic (AR), nonallergic (NAR), or mixed, and depending on the etiology and severity, patients experience various degrees of rhinorrhea, obstruction, itching, and sneezing. Chronic AR is estimated to impact over 26.3% of the people in Taiwan. Inferior turbinate reduction can improve nasal obstruction symptoms, and posterior nasal nerve neurolysis can reduce symptoms caused by neurogenic hypersecretion. Blue\u2010laser posterior nasal neurolysis via dual\u2010layer nerve modulation provides a precise operation for chronic AR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, conducted at Shuang Ho Hospital in 2025, we compared the efficacy and safety of blue\u2010laser inferior turbinate reduction (BITR) combined with blue\u2010laser posterior nasal nerve neurolysis (BPN3). In total, 42 adult patients with CR who had not responded adequately to at least 3\u2009months of drug therapy (\u2265\u20093\u2009months) were included. The primary outcomes were the 24\u2010h reflective Total Nasal Symptoms Score (rTNSS) and the Nasal Obstruction Symptoms Evaluation (NOSE) scale score, which were compared and analyzed at the baseline, and 1 and 6\u2009months postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 1\u2009month, all patients exhibited significant improvements. Mean rTNSS had decreased from 7.9\u2009\u00b1\u20092.1 to 1.7\u2009\u00b1\u20091.6 (\u221278.5%) and NOSE scores improved from 69.3\u2009\u00b1\u200911.4 to 7.0\u2009\u00b1\u20096.5 (\u221289.9%). At 6\u2009months, the mean rTNSS had decreased from 7.9\u2009\u00b1\u20092.1 to 1.9\u2009\u00b1\u20091.8 (\u221276.0%) and NOSE scores had improved from 69.3\u2009\u00b1\u200911.4 to 6.6\u2009\u00b1\u20095.3 (\u221292.0%). Overall, no serious complications occurred during the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BPN3 combined with inferior turbinate reduction provides superior symptom relief, particularly for rhinorrhea, with excellent safety and tolerability. This dual layer nerve modulation operation offers a promising minimally invasive treatment for medication\u2010refractory chronic AR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>IV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70468","type":"journal-article","created":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T15:11:48Z","timestamp":1783869108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blue\u2010Laser Posterior Nasal Neurolysis via Dual Layer Nerve Modulation for Chronic Rhinitis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-2691","authenticated-orcid":false,"given":"Lok\u2010Yee Joyce","family":"Li","sequence":"first","affiliation":[{"name":"Department of Environmental and Occupational Medicine National Taiwan University Hospital Hsin\u2010Chu Branch  Hsinchu Taiwan"},{"name":"School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Department of Industrial Engineering and Industrial Management National Tsing Hua University  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering and Industrial Management National Tsing Hua University  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Yu","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering Imperial College London  London UK"},{"name":"School of Respiratory Therapy, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"TMU Research Center of Artificial Intelligence in Medicine and Health Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Majumdar","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biology University of California  Riverside California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinn\u2010Moon","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University  Hsinchu Taiwan"},{"name":"Department of Biological Science and Technology National Yang Ming Chiao Tung University  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7443-2119","authenticated-orcid":false,"given":"Cheng\u2010Jung","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Department of Otolaryngology Shuang Ho Hospital, Taipei Medical University  Taipei Taiwan"},{"name":"Ph.D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University  Hsinchu Taiwan"},{"name":"Allergy and Rhinology Quality HealthCare Center  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0963"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X211041124"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23068"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010026\u201010271\u20103"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010026\u201004835\u20102"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21991"},{"issue":"12","key":"e_1_2_11_8_1","first-page":"1537","article-title":"Modified Technique Improves Efficacy for In\u2010Office Posterior Nasal Nerve Ablation","volume":"12","author":"Gorelik D.","year":"2022","journal-title":"International Forum of Allergy and Rhinology"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70468","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.70468","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:15:31Z","timestamp":1787840131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.70468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,12]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/lio2.70468"],"URL":"https:\/\/doi.org\/10.1002\/lio2.70468","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,12]]},"assertion":[{"value":"2026-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70468"}}