{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:40:30Z","timestamp":1787841630274,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","award":["ERP\u20102022\u201013019"],"award-info":[{"award-number":["ERP\u20102022\u201013019"]}],"id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate postoperative outcomes and patient\u2010reported recovery in adult BiZact tonsillectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective multicenter study, consecutive adults underwent BiZact tonsillectomy at five institutions. Intraoperative variables included tonsil size, adhesion grade, operative time, and estimated blood loss. Patient\u2010reported outcomes were collected preoperatively and on postoperative day 1, week 1, and week 8, including pharyngeal pain and otalgia, oral intake, daily activity, bleeding events, time to complete recovery, and satisfaction. Health\u2010related quality of life was assessed using the Tonsillectomy Outcome Inventory\u201314 (TOI\u201014) preoperatively and at week 8. Time to complete recovery was analyzed using Kaplan\u2013Meier methods, and perioperative outcomes were compared by peritonsillar adhesion severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 220 enrolled patients, 211 (95.9%) were analyzed (mean age 31.7\u2009years; 60.7% female). Mean operative time was 14.7\u2009min and mean blood loss was 6.5\u2009mL. Pharyngeal pain and otalgia peaked at week 1 and improved by week 8 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). TOI\u201014 improved from 27.6\u2009\u00b1\u200915.9 to 2.9\u2009\u00b1\u20095.6 at week 8. Postoperative bleeding was reported in 31 patients (14.7%) and 4 patients (1.9%) required operative hemostasis. Median recovery was 14\u2009days for normal activity and regular diet, and 19\u2009days for complete pain resolution. The mean satisfaction score was 9.2\u2009\u00b1\u20091.4. Higher adhesion grades increased operative time and blood loss, but did not affect postoperative pain, functional recovery, bleeding rates, or TOI\u201014 improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BiZact tonsillectomy was associated with acceptable perioperative outcomes and similar patient\u2010reported recovery patterns across adhesion severity groups, although these findings should be interpreted descriptively in the absence of a control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70482","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:03:17Z","timestamp":1783688597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adult\n                    <scp>BiZact<\/scp>\n                    Tonsillectomy: A Prospective Multicenter Study of Outcomes and Patient\u2010Reported Recovery"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-1361","authenticated-orcid":false,"given":"Gene","family":"Huh","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, St. Vincent's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Boramae Medical Center Seoul Metropolitan Government\u2010Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1158-0974","authenticated-orcid":false,"given":"Young\u2010Hoon","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Bucheon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Ook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9551-9571","authenticated-orcid":false,"given":"Chung\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Eunpyeong St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Hak","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Yeouido St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Cheju Halla Hospital  Jeju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geun\u2010Jeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Yeouido St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-8952","authenticated-orcid":false,"given":"Hyun\u2010Bum","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Daejeon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooin","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Eunpyeong St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Hae","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, St. Vincent's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wjorl.2017.01.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2015.00584"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2009.11.011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010023\u201007931\u2010z"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070\u2010017\u20101190\u20106"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2022.103547"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13273"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2022.111165"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.14140"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106\u2010012\u20102545\u20107"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2017.07.018"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2013.6.2.90"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24958"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otoeng.2015.01.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.48655"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010020\u201005832\u2010z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)00519\u20106"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3310\/YKUR3660"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2014.02.007"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24541"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.12.005"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420987438"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070\u2010011\u20100268\u20109"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154561"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.488"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.70482","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:16:06Z","timestamp":1787840166000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.70482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/lio2.70482"],"URL":"https:\/\/doi.org\/10.1002\/lio2.70482","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"assertion":[{"value":"2026-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70482"}}