{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:40:37Z","timestamp":1787841637199,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate clinicopathological factors associated with survival and recurrence in patients with T1N0 lower lip squamous cell carcinoma (LSCC), with particular attention to depth of invasion (DOI), perineural invasion (PNI), and neck management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single\u2010center cohort included 61 surgically treated patients with T1N0 lower LSCC. Overall survival (OS) and disease\u2010free survival (DFS) were analyzed using Kaplan\u2013Meier methods and Cox regression. A prespecified multivariable model included age, tumor diameter, and DOI. Exploratory recurrence analyses were also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort comprised 50 men and 11 women, with a mean age of 64.8\u2009years. Estimated 5\u2010year OS and DFS were 84.8% and 79.2%, respectively. Recurrence occurred in six patients (9.8%), including four local and two regional recurrences; one patient died of lower lip cancer. In univariable Cox analysis, increasing DOI was associated with worse OS (HR 1.15\/mm, 95% CI 1.02\u20131.30;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024), and PNI showed the strongest adverse signal for OS (HR 7.31, 95% CI 2.20\u201324.32;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and DFS (HR 5.63, 95% CI 1.81\u201317.58;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Neck dissection was associated with improved OS and DFS in univariable analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">T1N0<\/jats:styled-content>\n                      lower\n                      <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content>\n                      showed low recurrence and very low disease\u2010specific mortality.\n                      <jats:styled-content style=\"fixed-case\">PNI<\/jats:styled-content>\n                      showed the strongest adverse prognostic signal, although interpretation is limited by the small number of\n                      <jats:styled-content style=\"fixed-case\">PNI<\/jats:styled-content>\n                      \u2010positive cases. Neck dissection was associated with improved\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>\n                      in univariable analyses, but this finding should be interpreted cautiously in the context of surgeon\u2010specific practice variation and limited event numbers. Prospective studies are needed to define risk\u2010stratified neck management in\n                      <jats:styled-content style=\"fixed-case\">T1N0<\/jats:styled-content>\n                      disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70493","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:05:54Z","timestamp":1783339554000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Factors and Survival Outcomes in\n                    <scp>T1N0<\/scp>\n                    Lower Lip Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9728-3040","authenticated-orcid":false,"given":"Emre","family":"Demirel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Samsun City Hospital  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"G\u00f6lhisar State Hospital  Burdur Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan","family":"\u00c7olak","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Ondokuz May\u0131s University Faculty of Medicine  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-6012","authenticated-orcid":false,"given":"Esra","family":"Kavaz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Ondokuz May\u0131s University Faculty of Medicine  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