{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:40:40Z","timestamp":1787841640971,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) is highly associated with obesity and often results in significant cardiovascular complications. This study aimed to assess cardiovascular outcomes in OSA patients treated with GLP\u20101 agonists (GLP1a) versus CPAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort analysis using TriNetX datasets (2014\u20132024) compared cardiovascular outcomes between four pairs of cohorts, after propensity score matching (PSM): OSA+CPAP +\/\u2212 GLP1a, OSA+Obesity + CPAP +\/\u2212 GLP1a, OSA\u2014CPAP +\/\u2212 GLP1a, and OSA+Obesity\u2014CPAP +\/\u2212 GLP1a. Outcomes of interest include myocardial infarction, heart failure, stroke, cardiac arrest, ventricular arrhythmias, atrial fibrillation\/flutter, pulmonary hypertension, and percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the non\u2010CPAP cohort, GLP\u20101a therapy showed decreased risks of myocardial infarction (RR 0.650 [0.523\u20130.808]), heart failure (RR 0.500 [0.357\u20130.701]), cardiac arrest (RR 0.300 [0.199\u20130.450]), ventricular arrhythmias (RR 0.385 [0.278\u20130.532]), atrial fibrillation\/flutter (RR 0.833 [0.762\u20130.912]), and PCI\/CABG (RR 0.333 [0.163\u20130.681]). No significant differences were observed in stroke or pulmonary hypertension between GLP1+ and GLP1\u2010 groups in this cohort. Among patients using CPAP, GLP1a use was associated with a decreased risk of atrial fibrillation\/flutter (RR 0.700 [0.542\u20130.905]), with no other differences observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study indicates that GLP\u20101 agonists may offer cardioprotective benefits not achieved with CPAP therapy in OSA patients. Our study indicates that a GLP\u20101 agonist prescription may be associated with improved cardiovascular outcomes; these associations were not observed with CPAP therapy prescription in OSA patients. Additional research is required to determine whether obesity status modulates the observed benefits among patients with OSA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70495","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T01:25:13Z","timestamp":1783992313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardio\u2010Protective Effect of\n                    <scp>GLP<\/scp>\n                    \u20101 Agonists in\n                    <scp>OSA<\/scp>\n                    Patients: A Study of Cardiovascular Risk"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3365-2072","authenticated-orcid":false,"given":"Morgan","family":"Lane","sequence":"first","affiliation":[{"name":"University of Tennessee Health Science Center College of Medicine  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Jin","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center College of Medicine  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6496-2977","authenticated-orcid":false,"given":"Boston","family":"Andersen","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center College of Medicine  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9540-087X","authenticated-orcid":false,"given":"Alec","family":"Kadrie","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center College of Medicine  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5887-408X","authenticated-orcid":false,"given":"Sage","family":"Hebert","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Thomson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Boyd","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(19)30198\u20105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2021.05.010"},{"key":"e_1_2_9_4_1","volume-title":"FDA Approves New Medication for Chronic Weight Management","author":"FDA Office of Media Affairs","year":"2023"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14\u20100500"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hjc.2018.11.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2024.107516"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases12090224"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.721135"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325\u2010022\u201002768\u2010y"},{"key":"e_1_2_9_11_1","first-page":"A4144","volume-title":"New Insights in Pathogenesis of Sleep Disordered Breathing","author":"Amin R. 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