{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:40:30Z","timestamp":1787841630281,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Nanofat is fat emulsified into micron\u2010sized particles. Unlike microfat, nanofat increases the release of adipose\u2010derived stem cells by destroying lipocytes. This study evaluated whether nanofat injection laryngoplasty alone leads to lasting bulking and sustained long\u2010term voice improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed patients with glottal insufficiency due to atrophy, paresis, or scarring who underwent operative (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913) or office\u2010based (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918) nanofat injection laryngoplasty. The average injected fat volume was 0.5\n                      <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                      per side. Median follow\u2010up was 12 \u00b1\u20094 months. Stroboscopy was used to assess vocal fold closure and vibration. Pre\u2010 and post\u2010Voice Handicap Index\u201010 (\n                      <jats:styled-content style=\"fixed-case\">VHI<\/jats:styled-content>\n                      \u201010) and Cepstral Spectral Index of Dysphonia scores were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">VHI<\/jats:styled-content>\n                      \u201010 scores improved significantly from pre\u2010 to post\u2010treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Improved glottic closure after nanofat injection correlated with improved voice. Unwanted stiffness was noted in only one case. Unwanted absorption occurred in the first year in nine patients (29%), whereas the remaining patients maintained good long\u2010term function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nanofat\u2010only lipoinjection is a potential alternative to microfat injection for the treatment of glottal insufficiency. Office\u2010based nanofat injection using a small\u2010gauge needle cannula is a practical alternative to operative microfat injection. Early absorption remains a challenge, and targeted overinjection and improved fat processing should be considered to optimize outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level 4. Retrospective case series.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70511","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:33:54Z","timestamp":1784385234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanofat for Injection Laryngoplasty: Office and Operative Results"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0144-5178","authenticated-orcid":false,"given":"Peak","family":"Woo","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahita","family":"Nourmahnad","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199205000-00005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(97)80083-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2023.09.029"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29802"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817739256"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11164806"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e3182592db1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31829fe1b0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.022"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpsam.2024.0385"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000009345"},{"key":"e_1_2_10_13_1","article-title":"Nanofat for Injection Laryngoplasty: A Preliminary Study of a New Substrate","volume":"26","author":"Gidumal S.","year":"2025","journal-title":"Journal of Voice"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699200903242988"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2013.04.002"},{"key":"e_1_2_10_16_1","first-page":"245","article-title":"Cepstral Voice Analysis: Link With Perception and Stroboscopy","volume":"119","author":"Dejonckere P. H.","year":"1998","journal-title":"Revue de Laryngologie Otologie Rhinologie"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489415595427"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06479-6"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10215034"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200207000-00017"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018579"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/ijms20215471","article-title":"Impact of the Different Preparation Methods to Obtain Human Adipose\u2010Derived Stromal Vascular Fraction Cells (AD\u2010SVFs) and Human Adipose\u2010Derived Mesenchymal Stem Cells (AD\u2010MSCs): Enzymatic Digestion Versus Mechanical Centrifugation","volume":"20","author":"Gentile P.","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_10_23_1","first-page":"8","article-title":"Subcutaneous Injections of Nanofat Adipose\u2010Derived Stem Cell Grafting in Facial Rejuvenation","volume":"8","author":"Menkes S.","year":"2020","journal-title":"Plastic and Reconstructive Surgery. Global Open"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29200"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/09636897231175968"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200312000-00013"},{"key":"e_1_2_10_27_1","article-title":"Technical Precision With Autologous Fat Grafting for Facial Rejuvenation: A Review of the Evolving Science","author":"Strong A. 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