{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:40:30Z","timestamp":1787841630225,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM202403005"],"award-info":[{"award-number":["SZSM202403005"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective(s)<\/jats:title>\n                    <jats:p>To classify adults by concordance between rhinitis symptoms and measured systemic allergen\u2010specific immunoglobulin E (sIgE) sensitization and to examine associated asthma and sinonasal burden patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed NHANES 2005\u20132006 adults aged 20\u2009years or older with positive examination weights. Rhinitis symptoms were defined as hay fever or nasal symptoms in the past 12\u2009months. Measured systemic sensitization was defined as at least 1 of 19 serum sIgE results\u2009&gt;\u2009=\u20090.35\u2009kU\/L. Survey\u2010weighted logistic regression estimated adjusted odds ratios (ORs) from outcome\u2010specific complete cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 4773 eligible adults, 4487 had complete phenotype data. A total of 4220 adults had complete data for the final model, which included 546 asthma cases. Weighted phenotype prevalence was 38.7% concordant negative, 24.6% isolated systemic sensitization, 17.7% isolated rhinitis symptoms, and 19.0% concordant positive. Compared with concordant negative adults, concordant positive adults had the highest odds of asthma (OR, 6.21; 95% CI, 4.73\u20138.16). Isolated systemic sensitization (OR, 2.57; 95% CI, 2.08\u20133.19) and isolated rhinitis symptoms (OR, 2.67; 95% CI, 2.10\u20133.40) were also associated with asthma. Isolated rhinitis symptoms were associated with sinus infection (OR, 3.16; 95% CI, 2.46\u20134.06) and modestly with sleep impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Rhinitis symptoms and measured systemic sensitization were related but noninterchangeable. Their concordance and discordance described clinically recognizable adult rhinitis phenotypes with distinct asthma and sinonasal burden patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70514","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:34:48Z","timestamp":1784345688000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Heterogeneity in Adult Rhinitis: Symptom\u2010Sensitization Concordance and Asthma Burden"],"prefix":"10.1002","volume":"11","author":[{"given":"Chong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Shenzhen Longgang Otolaryngology Hospital, Shenzhen Otolaryngology Research Institute  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Shenzhen Nanshan People's Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haigang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Shenzhen Nanshan People's Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7454-8250","authenticated-orcid":false,"given":"Xiaohua","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Shenzhen Nanshan People's Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.874114"},{"issue":"5","key":"e_1_2_11_3_1","first-page":"950","article-title":"Rhinitis Symptoms and IgE Sensitization as Risk Factors for Development of Later Allergic Rhinitis in Adults","volume":"78","author":"Bodtger U.","year":"2017","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.050"},{"issue":"5","key":"e_1_2_11_5_1","first-page":"364","article-title":"Local Allergic Rhinitis: Concept, Clinical Manifestations, and Diagnostic Approach","volume":"20","author":"Rond\u00f3n C.","year":"2010","journal-title":"Journal of Investigational Allergology & Clinical 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