{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:40:34Z","timestamp":1787841634842,"version":"build-2784847793"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n Post\u2010operative nausea and vomiting (PONV) is common following endoscopic skull base surgery despite multimodal prophylaxis and carries a risk of post\u2010operative bleeding and cerebrospinal fluid (CSF) leakage. This study aims to investigate if pre\u2010operative administration of the neurokinin\u20101 (NK\u20101) antagonist, aprepitant, reduces PONV in patients undergoing endoscopic skull base surgery.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective review of 58 patients undergoing endoscopic skull base surgery was performed. Demographic variables and clinical variables such as anesthesia type, procedural time, intraoperative CSF leak, and co\u2010administration of other antiemetics were collected. Primary outcome was PONV events, defined as the documentation of nausea and\/or vomiting in the medical record or use of rescue antiemetic therapy. Post\u2010operative bleeding and CSF leaks were recorded. Univariate and multivariate analyses were conducted in R with the following covariates: co\u2010administered antiemetics, TIVA use, smoking status, ASA score, procedural duration, and intraoperative CSF leak.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of patients who received aprepitant, 42.9% developed PONV compared to 43.2% in the non\u2010aprepitant group. On univariate analysis, there was no difference in PONV (OR 0.98,\n p<\/jats:italic>\n \u2009=\u20091.00), vomiting (OR 0.33,\n p<\/jats:italic>\n \u2009=\u20090.30), or post\u2010operative bleeding (OR 0.87,\n p<\/jats:italic>\n \u2009=\u20091.00) between groups. Multivariate regression showed no association between PONV and aprepitant (OR 0.52,\n p<\/jats:italic>\n \u2009=\u20090.32). Subgroup analysis of patients undergoing transsphenoidal surgery showed no association of PONV and aprepitant (OR 0.45,\n p<\/jats:italic>\n \u2009=\u20090.34).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n PONV occurs in nearly half of patients undergoing endonasal skull base surgery. Pre\u2010operative administration of aprepitant was not associated with reduced risk of developing PONV.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 3.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lio2.70520","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:55:51Z","timestamp":1785556551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Aprepitant on Post\u2010Operative Nausea and Vomiting in Endoscopic Skull Base Surgery"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3954-2988","authenticated-orcid":false,"given":"Anuj U.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of California, Davis Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Sun","sequence":"additional","affiliation":[{"name":"University of California, Davis School of Medicine Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hewitt","family":"Chang","sequence":"additional","affiliation":[{"name":"University of California, Davis School of Medicine Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Clouse","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California, Davis Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiarash","family":"Shahlaie","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California, Davis Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Bradley","family":"Strong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of California, Davis Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Steele","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of California, Davis Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000221185.08155.80"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23208"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658\u2010354X.136424"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000005969"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001829"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.095"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000263277.35140.a3"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep125"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31822b6932"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540\u2010017\u20102363\u2010x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.21832.1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004833"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e31826f0a0a"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13472"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.70520","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:16:18Z","timestamp":1787840178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.70520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/lio2.70520"],"URL":"https:\/\/doi.org\/10.1002\/lio2.70520","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"2026-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70520"}}