{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:40:32Z","timestamp":1787841632432,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2025IL0019"],"award-info":[{"award-number":["2025IL0019"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To analyze olfactory\u2010related quality of life (QOL), assess subjective and psychophysical olfactory dysfunction, and identify factors associated with changes in olfactory\u2010related QOL following endoscopic endonasal transsphenoidal approach (EETSA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 112 patients who underwent an EETSA between August 2019 and June 2022. Participants completed assessments before and after surgery, including the YSK Olfactory Function (YOF) test, the Questionnaire of Olfactory Disorders (QOD; comprising QOD\u2010LQ, QOD\u2010S, QOD\u2010P, and QOD\u2010VAS subscales, with higher scores indicating greater QOL impairment), the 36\u2010Item Short\u2010Form Survey (SF\u201036), and the 22\u2010Item Sino\u2010Nasal Outcome Test (SNOT\u201022). Clinical characteristics, intraoperative events, and postoperative complications were reviewed retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Post\u2010EETSA assessment revealed significant increases in mean QOD\u2010LQ, QOD\u2010P, and QOD\u2010VAS scores, while neither physical health scores (SF\u201036 PCS) nor mental health scores (SF\u201036 MCS) showed significant changes following EETSA. Twenty\u2010seven patients (24.1%) reported subjective olfactory dysfunction through SNOT\u201022 with normal YOF test results. \u201cDecreased sense of smell\u201d scores in SNOT\u201022 demonstrated significant positive correlations with QOD\u2010LQ, QOD\u2010P, and QOD\u2010VAS scores. Female patients exhibited significantly greater deterioration in QOD\u2010LQ and QOD\u2010VAS than males, with female sex an independent factor for both. Postoperative CSF leakage (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093) was independently associated with QOD\u2010LQ deterioration, although the sample size was small.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Post\u2010EETSA evaluation should emphasize both olfactory\u2010related QOL and subjective olfactory dysfunction rather than focusing solely on psychophysical olfactory function. Comprehensive pre\u2010 and post\u2010operative counseling addressing these aspects is essential for optimal patient care, with particular attention given to high\u2010risk populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70529","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T01:50:21Z","timestamp":1786153821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Olfactory\u2010Related Quality of Life After Endoscopic Transsphenoidal Surgery"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1701-6263","authenticated-orcid":false,"given":"Yeong Ju","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and 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