{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:05:20Z","timestamp":1790165120788,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective(s)<\/jats:title>\n                    <jats:p>Radiological intratumoral calcifications in sinonasal adenocarcinoma have been scarcely investigated. This study aimed to assess their prevalence and evaluate their potential prognostic significance and to examine its association with surgical resectability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective single\u2010center study including patients treated with curative intent for sinonasal adenocarcinoma. Clinical, pathological, treatment, and computed tomography (CT) data were reviewed. Intratumoral diffuse calcifications were assessed on preoperative CT. Associations with tumor characteristics, surgical outcomes, and survival were analyzed using appropriate statistical methods, including Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010six patients were included. Intratumoral calcifications were identified in 24 patients (25%). Compared with patients without calcifications, those with calcifications more frequently had locally advanced tumors (pT3\u20134: 79.2% vs. 47.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013; pT4: 62.5% vs. 31.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025), were more likely to receive induction chemotherapy (33.3% vs. 9.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015), and had a higher rate of incomplete resection (R2: 20.0% vs. 1.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Histological subtype and differentiation grade were similar between groups. The association with R2 resection persisted after adjustment for pT stage (penalized logistic regression: OR 7.74, 95% CI 1.26\u201382.61;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026). In univariable analysis, calcifications were associated with worse disease\u2010free survival (HR 2.36, 95% CI 1.23\u20134.54;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010), but this association did not persist after adjustment for pT stage (HR 1.47, 95% CI 0.76\u20132.88;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.26) or in multivariable analysis (HR 1.41, 95% CI 0.70\u20132.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.34). Calcifications were not associated with overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intratumoral radiological calcifications were present in 25% of sinonasal adenocarcinomas and were associated with more advanced local disease and a higher risk of incomplete resection. Although associated with poorer disease\u2010free survival in unadjusted analyses, this effect was attenuated after adjustment for tumor stage. These findings suggest that calcifications primarily reflect local tumor extent; although not an independent survival factor, their independent association with incomplete resection may make them a useful preoperative marker of surgical difficulty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70565","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:45:22Z","timestamp":1790163922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiological Tumor Calcification in Sinonasal Adenocarcinoma: Prevalence and Prognostic Implications"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-7927","authenticated-orcid":false,"given":"Julia","family":"Fanchette","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Lariboisi\u00e8re Hospital, APHP Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-339X","authenticated-orcid":false,"given":"Florian","family":"Chatelet","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Lariboisi\u00e8re Hospital, APHP Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"ECSTRRA Team Universit\u00e9 Paris Cit\u00e9, IRSL, INSERM UMR 1342  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7489-1105","authenticated-orcid":false,"given":"Melania","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Lariboisi\u00e8re Hospital, APHP Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Boukebous","sequence":"additional","affiliation":[{"name":"ECAMO Team INSERM UMR1153, Center of Research in Epidemiology and StatisticS, H\u00f4tel\u2010Dieu Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4805-4908","authenticated-orcid":false,"given":"Alessandro","family":"Vinciguerra","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Lariboisi\u00e8re Hospital, APHP Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Lariboisi\u00e8re Hospital, APHP Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Pierre","family":"Guichard","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Lariboisi\u00e8re Hospital, APHP Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Al Tabaa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology NOVO Hospital  Pontoise France"},{"name":"CY Cergy Paris Universit\u00e9, ERRMECe  Cergy\u2010Pontoise France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9768-9788","authenticated-orcid":false,"given":"Michel","family":"Wassef","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lariboisi\u00e8re Hospital, APHP Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homa","family":"Adle\u2010Biassette","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lariboisi\u00e8re Hospital, APHP Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Herman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Lariboisi\u00e8re Hospital, APHP Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9 INSERM UMR 1141  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Verillaud","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Lariboisi\u00e8re Hospital, APHP Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9 INSERM UMR 1141  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"A. 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