{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:58:23Z","timestamp":1790744303084,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001855"],"award-info":[{"award-number":["UL1TR001855"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n Childhood HPV vaccination reduces oropharyngeal cancer (OPC) incidence, but evidence regarding vaccination after HPV exposure or OPC diagnosis remains limited. While benefits are documented in cervical dysplasia, anogenital cancers, and laryngeal papillomatosis, the impact on OPC outcomes is unknown.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Using the prospective TrinetX database, OPC patients were stratified by HPV vaccination status. Vaccinated patients were divided into three cohorts: vaccinated before OPC diagnosis, within 1\u2009year after diagnosis, and at any timepoint. Cohorts were propensity\u2010matched with unvaccinated controls by age, race, ethnicity, sex, and cancer stage. Survival outcomes were assessed at 2, 5, and >\u20095\u2009years post\u2010diagnosis using absolute risk reduction and Kaplan\u2013Meier analyses.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Propensity matching yielded 162 patients vaccinated at any time, 24 vaccinated within 1\u2009year post\u2010diagnosis, and 79 vaccinated pre\u2010diagnosis, with equal matched controls showing no demographic differences. Women predominated among those vaccinated before OPC diagnosis (73%), while men comprised 80% of those vaccinated after diagnosis. HPV vaccination was associated with improved overall survival at 2\u2009years (97% vs. 91%,\n p<\/jats:italic>\n \u2009=\u20090.29), 5\u2009years (97% vs. 89%,\n p<\/jats:italic>\n \u2009=\u20090.019), and >\u20095\u2009years (93% vs. 74%,\n p<\/jats:italic>\n \u2009=\u20090.0003) for the vaccinated\u2010anytime cohort versus never\u2010vaccinated patients, translating to 5.14% absolute risk reduction at 5\u2009years. Trends persisted but lacked statistical significance in pre\u2010 and post\u2010diagnosis vaccination subgroups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n HPV vaccination after HPV exposure was associated with improved survival in OPC patients. However, imperfect HPV ascertainment, small vaccinated cohorts, and potential selection bias, including a healthy vaccinee effect, preclude causal inference, and this association should not be interpreted as evidence of a therapeutic effect. Prospective and randomized clinical trials are needed to determine whether adjuvant HPV vaccination confers a true survival benefit in OPC. Given the low morbidity of therapy and high potential survival impact, a clinical trial is warranted.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 3.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lio2.70573","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:19:51Z","timestamp":1790741991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjuvant\n HPV<\/scp>\n Vaccination and Survival in Oropharyngeal Squamous Cell Carcinoma: An Exploratory Analysis of a Real\u2010World Database"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7986-6119","authenticated-orcid":false,"given":"Mary Elizabeth","family":"Kim","sequence":"first","affiliation":[{"name":"Caruso Department of Otolaryngology\u2013Head and Neck Surgery Keck School of Medicine of University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Herrera","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of the University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Han","sequence":"additional","affiliation":[{"name":"Caruso Department of Otolaryngology\u2013Head and Neck Surgery Keck School of Medicine of University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Hur","sequence":"additional","affiliation":[{"name":"Caruso Department of Otolaryngology\u2013Head and Neck Surgery Keck School of Medicine of University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7388-6373","authenticated-orcid":false,"given":"Niels","family":"Kokot","sequence":"additional","affiliation":[{"name":"Caruso Department of Otolaryngology\u2013Head and Neck Surgery Keck School of Medicine of University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6140-0935","authenticated-orcid":false,"given":"Mark S.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, Irvine Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"5","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41571-022-00603-7","article-title":"HPV\u2010Associated Oropharyngeal Cancer: Epidemiology, Molecular Biology and Clinical Management","volume":"19","author":"Lechner M.","year":"2022","journal-title":"Nature Reviews Clinical Oncology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/S1470-2045(20)30524-6","article-title":"Efficacy of the Bivalent HPV Vaccine Against HPV 16\/18\u2010Associated Precancer: Long\u2010Term Follow\u2010Up Results From the Costa Rica Vaccine Trial","volume":"21","author":"Porras C.","year":"2020","journal-title":"Lancet Oncology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/S0140-6736(21)02178-4","article-title":"The Effects of the National HPV Vaccination Programme in England, UK, on Cervical Cancer and Grade 3 Cervical Intraepithelial Neoplasia Incidence: A Register\u2010Based Observational Study","volume":"398","author":"Falcaro M.","year":"2021","journal-title":"Lancet"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines9050410","article-title":"Adjuvant HPV Vaccination to Prevent Recurrent Cervical Dysplasia After Surgical Treatment: A Meta\u2010Analysis","volume":"9","author":"Di Donato V.","year":"2021","journal-title":"Vaccine"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejogrb.2023.04.014","article-title":"The Efficacy of Human Papillomavirus Prophylactic Vaccination After Conization in Preventing Cervical Intraepithelial Neoplasia Recurrence: A Prospective Observational Study in China","volume":"286","author":"Chen M.","year":"2023","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejogrb.2025.113994","article-title":"Impact of Human Papillomavirus 9\u2010Valent Vaccine on Viral Clearance After Surgical Treatment: A Single\u2010Center Retrospective Observational Study","volume":"310","author":"Palumbo M.","year":"2025","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/LARY.32123"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/infdis\/jiy616","article-title":"Therapeutic Use of the Human Papillomavirus Vaccine on Recurrent Respiratory Papillomatosis: A Systematic Review and Meta\u2010Analysis","volume":"219","author":"Rosenberg T.","year":"2019","journal-title":"Journal of Infectious Diseases"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1002\/lary.30560","article-title":"The Efficacy of Human Papillomavirus Vaccination as an Adjuvant Therapy in Recurrent Respiratory Papillomatosis","volume":"133","author":"Ponduri A.","year":"2023","journal-title":"Laryngoscope"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","DOI":"10.3390\/life11111279","article-title":"HPV and Recurrent Respiratory Papillomatosis: A Brief Review","volume":"11","author":"Ouda A. M.","year":"2021","journal-title":"Life"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1016\/S2214-109X(20)30459-9","article-title":"Estimates of the Global Burden of Cervical Cancer Associated With HIV","volume":"9","author":"Stelzle D.","year":"2021","journal-title":"Lancet Global Health"},{"key":"e_1_2_11_13_1","unstructured":"American Academy of Otolaryngology\u2010Head and Neck Surgery (AAO\u2010HNS) \u201cPosition Statement: Recurrent Respiratory Papillomatosis and Gardasil Vaccination \u201d2024 https:\/\/www.entnet.org\/resource\/position\u2010statement\u2010recurrent\u2010respiratory\u2010papillomatosis\u2010and\u2010gardasil\u2010vaccination\/."},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/LGT.0000000000000703","article-title":"ASCCP Committee Opinion: Adjuvant Human Papillomavirus Vaccine for Patients Undergoing Treatment for Cervical Intraepithelial Neoplasia","volume":"27","author":"Sharpless K. E.","year":"2022","journal-title":"Journal of Lower Genital Tract Disease"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.70573","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:19:56Z","timestamp":1790741996000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.70573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/lio2.70573"],"URL":"https:\/\/doi.org\/10.1002\/lio2.70573","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70573"}}