{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:58:14Z","timestamp":1790913494561,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Nasal airway obstruction (NAO) can be due to deviation of the cartilaginous and bony nasal septum. Correcting the caudal cartilaginous septum can be technically challenging. This study aims to evaluate the safety and effectiveness of a bioabsorbable submucosal septal implant (SeptAlign; Spirair Inc.) for minimally invasive correction of cartilaginous nasal septal deviation (NSD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective cohort study conducted at nine otolaryngology clinics in the USA. Subjects underwent placement of the implant alone or with concurrent inferior turbinate reduction (ITR). Percentage reductions relative to baseline in the mean Nasal Obstruction Symptom Evaluation (NOSE) score were calculated at 3 and 6\u2009months postprocedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 80 subjects (92.5% with moderate\u2010to\u2010severe NSD), NOSE scores decreased by 63.2% (from 67.5 at baseline to 26.0 at 3\u2009months and 23.6 at 6\u2009months;\n                      <jats:italic>p<\/jats:italic>\n                      values &lt;\u20090.0001). Overall, 85.9% of subjects at 3\u2009months and 89.9% at 6\u2009months were considered responders. The sub\u2010group with concurrent turbinate reduction had 88.2% responders and the sub\u2010group with the implant alone had 91.4% responders at 6\u2009months. Subjects returned to work a median of 1\u2009day after the procedure, which was performed in\u2010office under local anesthesia in 46.3% of cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The septal implant was an effective treatment for NAO symptoms via NSD repair and was generally safe and well tolerated. It straightens cartilaginous NSD via mechanical traction without the need for resection and may be an attractive alternative to conventional septoplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70579","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:51:07Z","timestamp":1790913067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Effectiveness of a Bioabsorbable Septal Implant for Cartilaginous Nasal Septal Deviation"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2020-6386","authenticated-orcid":false,"given":"Thomas S.","family":"Higgins","sequence":"first","affiliation":[{"name":"Kentuckiana ENT, a Division of ENT Care Centers  Louisville Kentucky USA"},{"name":"Otolaryngology\u2010Head and Neck Surgery, University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry P.","family":"Barham","sequence":"additional","affiliation":[{"name":"Otolaryngology, Sinus and Nasal Specialists of Louisiana  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg E.","family":"Davis","sequence":"additional","affiliation":[{"name":"Proliance Surgeons  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Davis","sequence":"additional","affiliation":[{"name":"Breathe Clear Institute  Torrance California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Fatakia","sequence":"additional","affiliation":[{"name":"ENT &amp; Allergy of New Orleans  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora W.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Albany ENT &amp; Allergy Services, PC  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sillers","sequence":"additional","affiliation":[{"name":"Otolaryngology\u2014Head and Neck Surgery, University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Yen","sequence":"additional","affiliation":[{"name":"Specialty Physician Associates  Bethlehem Pennsylvania USA"},{"name":"Otolaryngology\u2014Head and Neck Surgery, St. Luke's University Health Network  Bethlehem Pennsylvania 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