{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:50:41Z","timestamp":1791597041686,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n The retrospective cohort study compares tube location in the anterior\u2010inferior quadrant versus the posterior\u2010inferior quadrant and time of tube retention along with the risk of early extrusion and perforation. The study hypothesis holds that both anterior\u2010inferior placement and posterior\u2010inferior placement are equally effective and safe locations for tube placement with equal tube retention and risk for tympanic membrane perforation.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n An IRB\u2010approved retrospective chart review was completed at a major Academic Center's Children's Hospital. The study included data from children who underwent tube placement between 6\u2009months and 16\u2009years old between February 2019\u2013February 2021. Demographics and clinical factors were collected.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of the 905 patients and 1800 ears, a total of 1584 ears had tubes placed in the anterior\u2010inferior quadrant and 216 were placed in the posterior\u2010inferior quadrant. Tubes remained in place for 487\u2009days in the anterior\u2010inferior quadrant and 456 in the posterior\u2010inferior quadrant. The risk of perforation was 1.4% in the anterior\u2010inferior quadrant and 0% in our study for the posterior\u2010inferior quadrant. Univariate analysis showed a difference but was not significantly different (1.10 [0.95, 1.27]). This slight difference was confirmed by multivariate analysis HR\u2009=\u20091.11 [0.96, 1.30].<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study shows that there is no difference in tube retention or risk of tympanic membrane perforation based on location of tympanostomy tube placement either in the anterior\u2010inferior quadrant versus the posterior\u2010inferior quadrant. Factors associated with earlier tube extrusion included older age, cleft palate, and recurrent acute otitis media as the diagnosis. T\u2010tubes had slower extrusion, as expected.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 3<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lio2.70590","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:19:55Z","timestamp":1791595195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tympanostomy Tube Placement: The Effect of Location on Tube Retention and Risk of Perforation"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2473-3690","authenticated-orcid":false,"given":"Jason G.","family":"May","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Medical College of Georgia at Augusta University, Children's Hospital of Georgia Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Y.","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Missouri Medical Center Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob A.","family":"Thoenen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Missouri Medical Center Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliav","family":"Gov\u2010Ari","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Missouri Medical Center Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo L.","family":"Rivera","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Missouri Medical Center Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820917397"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25127"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812468849"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1936.00640050613006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100062800"},{"key":"e_1_2_9_7_1","first-page":"1","article-title":"Pediatric Tympanostomy Tube Assessment via Deep Learning","volume":"45","author":"Chang K. M.","year":"2024","journal-title":"American Journal of Otolaryngology\u2014Head and Neck Medicine and Surgery"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2020.110140"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0145561320929885"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2022.111210"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.4.417"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.70590","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:19:56Z","timestamp":1791595196000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.70590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/lio2.70590"],"URL":"https:\/\/doi.org\/10.1002\/lio2.70590","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70590"}}