{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:48:20Z","timestamp":1791809300611,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the incremental prognostic value of blood eosinophil count (BEC) and Lund\u2013Mackay (LM) ethmoid score beyond age and asthma for recurrence after endoscopic sinus surgery (ESS) in adults with chronic rhinosinusitis with nasal polyps (CRSwNP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort included adults with CRSwNP undergoing ESS from January 2022 to November 2024. The outcome was endoscopically confirmed recurrence. Cox models included age and asthma, then added BEC and LM ethmoid score. Performance was evaluated at 36\u2009months and internally validated using 1000 bootstrap resamples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 157 patients, 51 (32.5%) experienced recurrence; 36\u2010month recurrence\u2010free survival was 72.5% (95% confidence interval [CI], 64.7%\u201378.9%). Earlier recurrence was associated with age (adjusted hazard ratio [HR] per 10\u2009years, 1.26; 95% CI, 1.03\u20131.53), asthma (HR, 2.00; 95% CI, 1.03\u20133.90), BEC (HR per 0.1\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L, 1.23; 95% CI, 1.12\u20131.36), and LM ethmoid score (HR per point, 1.29; 95% CI, 1.13\u20131.47). Adding BEC and LM ethmoid score reduced the Akaike information criterion from 476.3 to 458.6 and 446.1. Apparent and optimism\u2010corrected 36\u2010month area under the curve values were 0.818 (bootstrap 95% interval, 0.747\u20130.896) and 0.804; corrected C\u2010index and Brier score were 0.756 and 0.154.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BEC and LM ethmoid score provided complementary information beyond age and asthma. External validation and recalibration are required before clinical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70594","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:15:19Z","timestamp":1791807319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood Eosinophil Count and Lund\u2013Mackay Ethmoid Score as Predictors of Recurrence After Endoscopic Sinus Surgery in\n                    <scp>CRSwNP<\/scp>"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3357-6220","authenticated-orcid":false,"given":"Zikang","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Third Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Third Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Third Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiansheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Third Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.600"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22741"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26391"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601\u2010019\u20100269\u20104"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.08.007"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12644"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2020.1844288"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22355"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S536368"},{"issue":"4","key":"e_1_2_12_11_1","first-page":"183","article-title":"Staging in Rhinosinusitis","volume":"31","author":"Lund V. 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