{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:36:03Z","timestamp":1793194563637,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010804","name":"Faculty of Medicine, Prince of Songkla University","doi-asserted-by":"publisher","award":["REC 61\u2010142\u201013\u20101"],"award-info":[{"award-number":["REC 61\u2010142\u201013\u20101"]}],"id":[{"id":"10.13039\/501100010804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify nutrition\u2010related predictors of treatment interruption during concurrent chemoradiotherapy (CCRT), the primary outcome and to determine the secondary impact of interruption on 5\u2010year overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analyzed 440 head and neck cancer (HNC) patients receiving definitive CCRT (January 2013 to December 2016) at a tertiary academic center. Treatment interruption was defined as radiotherapy total treatment time\u2009&gt;\u200956\u2009days or cumulative delay\u2009&gt;\u20097\u2009days, and as chemotherapy delay\u2009&gt;\u20097\u2009days or premature discontinuation. Multivariable logistic regression identified independent predictors; Kaplan\u2013Meier analysis compared 5\u2010year OS by interruption status and tumor site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 440 patients (mean age 55\u2009years; 81.7% male), 52.3% experienced chemotherapy interruptions and 14.4% radiotherapy interruptions. Independent nutritional predictors of chemotherapy interruption were: serum albumin\u2009&lt;\u20093.5\u2009g\/dL (adjusted OR 2.54, 95% CI 1.19\u20135.43,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), pretreatment BMI category (overall\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032, driven mainly by a protective trend for BMI\u2009&gt;\u200925\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      [adjusted OR 0.55, 95% CI 0.30\u20131.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.051]; the &lt;\u200918.5\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      subgroup showed a nonsignificant increase in risk: adjusted OR 1.41, 95% CI 0.84\u20132.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.196), and oral feeding (vs. feeding tube as reference) (adjusted OR 2.27, 95% CI 1.07\u20134.76,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030). In non\u2010nasopharyngeal cancer, radiotherapy interruption significantly reduced 5\u2010year OS (14.3% vs. 29.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Chemotherapy interruptions did not significantly affect survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hypoalbuminemia (&lt;\u20093.5\u2009g\/dL), pretreatment BMI category, and feeding route independently predict chemotherapy interruptions in HNC. Radiotherapy interruptions significantly impair survival in non\u2010nasopharyngeal cancers. These readily available markers should guide pretreatment nutritional optimization and feeding tube consideration in high\u2010risk patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.70595","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:35:25Z","timestamp":1791855325000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low Serum Albumin, Body Mass Index, and Feeding Route Predict Treatment Interruptions During Concurrent Chemoradiotherapy in Head and Neck Cancer: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8985-814X","authenticated-orcid":false,"given":"Kitti","family":"Jantharapattana","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine Prince of Songkla University  Hat Yai Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattarin","family":"Nilrat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine Prince of Songkla University  Hat Yai Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.04.014"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031317"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3181967dd0"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.07.2380"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4495-2"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.10.018"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1650"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20737"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11824"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S70204"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1477-7"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.62.173"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23538"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21044"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14133112"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.13028"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041277"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-023-07952-8"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0894-0959.2004.17603.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-9-69"},{"issue":"9","key":"e_1_2_12_24_1","first-page":"2652","article-title":"Low Preoperative Serum Albumin in Colon Cancer: A Risk Factor for Poor Outcome","volume":"25","author":"Lien Y. 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