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Historically thought of as aggressive tumors that warranted equally aggressive surgical intervention, evidence has emerged demonstrating that the vast majority of HNPGLs are slow growing and indolent. It is also now recognized that a large proportion of HNPGLs are hereditary with succinate dehydrogenase gene mutations typically implicated. These recent advances have led to significant changes in the way in which clinicians investigate and treat HNPGLs with most now opting for more conservative treatment strategies. However, a proportion of patients present with more aggressive disease and still require nonconservative treatment strategies. Recent studies have sought to determine in which groups of patients the morbidity associated with treatment is justified. We summarize the recent advances in the understanding and management of these tumors and we provide our recommendations regarding the management of HNPGLs.<\/jats:p>","DOI":"10.1002\/lio2.706","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T12:13:36Z","timestamp":1637928816000},"page":"93-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Contemporary management of paragangliomas of the head and neck"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2750-3057","authenticated-orcid":false,"given":"Eoin F.","family":"Cleere","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck surgery Beaumont Hospital  Dublin Ireland"},{"name":"Royal College of Surgeons in Ireland  Dublin 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