{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:37:59Z","timestamp":1792557479621,"version":"4.5.0"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To describe the off\u2010label intradermal use of ready\u2010to\u2010use liquid relabotulinumtoxinA (Relfydess) for symptomatic Frey's syndrome after parotidectomy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A 72\u2010year\u2010old man with gustatory sweating and flushing after total parotidectomy and adjuvant radiotherapy, who had previously responded to conventional botulinum toxin A, underwent gustatory provocation, clinical mapping, and intradermal relabotulinumtoxinA injections using a 1\u2010cm\n 2<\/jats:sup>\n grid. Clinical response and treatment\u2010related adverse events were assessed at 6\u2009weeks and 3\u2009months.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n At 6\u2009weeks and 3\u2009months, the patient reported symptom reduction comparable to his previous treatment with conventional botulinum toxin A. At 3\u2009months, repeat gustatory stimulation elicited no visible sweating. No treatment\u2010related adverse events were observed.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In this patient, ready\u2010to\u2010use liquid relabotulinumtoxinA provided sustained symptom control for 3\u2009months without observed adverse events. This formulation may offer a practical off\u2010label option for previously responsive patients, while product\u2010specific potency units should not be considered interchangeable.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 5<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lio2.70618","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:37:55Z","timestamp":1792553875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of Frey's Syndrome With \u201cReady to Use Liquid\u201d Relabotulinumtoxin A (Relfydess)"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6014-3700","authenticated-orcid":false,"given":"Loris","family":"Zoller","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Zurich Zurich Switzerland"},{"name":"University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Reddiess","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Zurich Zurich Switzerland"},{"name":"University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9095-6312","authenticated-orcid":false,"given":"Justus","family":"M\u00fcller\u2010Goebel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Zurich Zurich Switzerland"},{"name":"University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3867-234X","authenticated-orcid":false,"given":"Tobias","family":"Kleinjung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Zurich Zurich Switzerland"},{"name":"University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2428-897X","authenticated-orcid":false,"given":"Daniel","family":"Runggaldier","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Zurich Zurich Switzerland"},{"name":"University of Zurich Zurich Switzerland"},{"name":"Division of Phoniatrics and Speech Pathology, Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"issue":"8","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/lary.29414","article-title":"Different Surgical Strategies in the Prevention of Frey Syndrome: A Systematic Review and Meta\u2010Analysis","volume":"131","author":"De Virgilio A.","year":"2021","journal-title":"Laryngoscope"},{"issue":"2","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.otc.2015.10.010","article-title":"Auriculotemporal Syndrome (Frey Syndrome)","volume":"49","author":"Motz K. M.","year":"2016","journal-title":"Otolaryngologic Clinics of North America"},{"issue":"3","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2023.103818","article-title":"The Minor's Test in Frey Syndrome Treated With Botulinum Toxin: Methodology and Efficacy","volume":"44","author":"Marchese M. R.","year":"2023","journal-title":"American Journal of Otolaryngology"},{"key":"e_1_2_10_5_1","article-title":"Subject\u2010Reported Outcomes for Glabellar Line Improvement and Satisfaction With the Relabotulinumtoxina Ready\u2010To\u2010Use Liquid Formulation: Data From the Phase 3 READY\u20101 Trial","volume":"45","author":"Gold M. H.","year":"2025","journal-title":"Aesthetic Surgery Journal"},{"key":"e_1_2_10_6_1","unstructured":"Swissmedic \u201cKurzbericht Arzneimittelzulassung Relfydess (Wirkstoff: Botulinum\u2010Toxin Typ A [Stamm I01]) \u201d(2025)."}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70618","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.70618","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.70618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:37:58Z","timestamp":1792553878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.70618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/lio2.70618"],"URL":"https:\/\/doi.org\/10.1002\/lio2.70618","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70618"}}