{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:07:55Z","timestamp":1775765275995,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skull base osteomyelitis (SBO) is an infection of the central cranial bones, most commonly resulting from contiguous spread of infection from adjacent head and neck structures. SBO is a well\u2010recognized complication of treatment of head and neck cancer (HNC) that results in significant morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective chart review of HNC patients diagnosed with SBO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SBO was commonly diagnosed with nasal endoscopy showing mucosal breakdown between the naso\/oropharynx and skull base and with characteristic changes on CT\/MRI. Culture data were often polymicrobial, inclusive of naso\/oropharyngeal flora, but half of the patients additionally had antibiotic\u2010resistant or atypical pathogens. The mean duration of antimicrobial therapy was 117 +\/\u2212 94\u2009days. Recurrent SBO was found in half of the patients, associated with <jats:italic>Pseudomonas aeruginosa<\/jats:italic> and with persistent defects in the mucosa abutting the skull base.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diagnosis and management of SBO in HNC patients are challenging. Recommendations to aid in clinical care are proposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>4, case series.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.719","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T07:47:51Z","timestamp":1641368871000},"page":"47-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Skull base osteomyelitis in patients with head and neck cancer: Diagnosis, management, and outcomes in a case series of 23 patients"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8986-5419","authenticated-orcid":false,"given":"Mary M.","family":"Czech","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine Stanford University School of Medicine  Stanford California 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Stanford California USA"},{"name":"Department of Neurology and Neurological Sciences Stanford University School of Medicine  Stanford California USA"},{"name":"Department of Neurosurgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora Y.","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine Stanford University School of Medicine  Stanford California 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