{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:07:07Z","timestamp":1791659227082,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR003100"],"award-info":[{"award-number":["TL1TR003100"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["1K23DC014758"],"award-info":[{"award-number":["1K23DC014758"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare long\u2010term outcomes of laryngeal cancer (LC) in people living with HIV (PLWH) versus uninfected individuals and determine how clinical and viral factors\u2014such as demographics, cancer stage, HIV viral load, and CD4 nadir\u2014contribute to these outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective case\u2013control study of 749 patients seen for LC at a single tertiary care center between 2003 and 2017. Of these, 22 had HIV at the time of LC diagnosis, and they were matched in a 1:4 ratio to uninfected controls based on sex, presence of smoking history, and age at cancer diagnosis. Kaplan\u2013Meier survival curves and Cox proportional hazards models were constructed to identify overall and disease\u2010free survival differences based on HIV status, as well as other clinical and viral factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to all uninfected individuals, PLWH were diagnosed with LC approximately 6\u2009years younger (<jats:italic>p<\/jats:italic>\u00a0=\u2009.013). 1\u2010, 2\u2010, and 5\u2010year overall survival for PLWH were 86.4% (63.4%\u201395.4%), 77.3% (53.7%\u201389.9%), and 65.8% (40.8%\u201382.2%), respectively following LC diagnosis, and HIV was not significantly associated with overall (HR\u00a0=\u00a03.34 [0.59\u201318.79]) or disease\u2010free survival (HR\u00a0=\u00a02.12 [0.71\u20136.36]). The incidence rate of locoregional recurrence among PLWH was 541 compared to 371 per 10,000 person\u2010years in controls, which were not significantly different (<jats:italic>p<\/jats:italic>\u00a0=\u2009.420). Furthermore, among PLWH, peak viral load and CD4 nadir were not associated with overall or disease\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While previous work has shown that HIV is associated with elevated risk of LC, survival did not differ significantly between PLWH and uninfected individuals in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.736","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T12:38:34Z","timestamp":1642595914000},"page":"153-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of human immunodeficiency virus status on laryngeal cancer survival and locoregional control"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6608-5877","authenticated-orcid":false,"given":"Samuel Franklin","family":"Weinreb","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3844-5999","authenticated-orcid":false,"given":"Krzysztof","family":"Piersiala","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Division of ENT Diseases, Department of Clinical Sciences, Intervention, and Technology Karolinska Institute  Stockholm Sweden"},{"name":"Department of Otorhinolaryngology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumon Ian","family":"Dhar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8471-5449","authenticated-orcid":false,"given":"Alexander T.","family":"Hillel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8925-0545","authenticated-orcid":false,"given":"Lee","family":"Akst","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8699-033X","authenticated-orcid":false,"given":"Simon R. 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