{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:53:57Z","timestamp":1773057237833,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of nicergoline to prevent temporary threshold shift (TTS) in military personnel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A randomized control trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two hundred and twenty\u2010four participants were enrolled. Nicergoline 30\u2009mg twice daily intake was prescribed to the study group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0119) for 3\u2009weeks. The placebo was prescribed to the control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0105) for 3\u2009weeks, as well. Audiometric thresholds were measured at baseline and within 24\u2009h after the participants attended a 1\u2010day weapons firing practice. During the firing practice, all participants had to wear foam earplugs. The TTS was assessed by using a variety of published significant threshold shift (STS) definitions. Additionally, the effects of the treatment group on the magnitude of pre\u2010 to postexposure threshold shifts were estimated. Tinnitus and other adverse effects of the medication were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of STS was 65.4% from the study group and 75% from the control group. The negative STS (thresholds improved) was 68.6% from the study group and 44.7% from the control group. The positive STS (thresholds worsened) from the study group and the control group was 31.4% and 55.3%, respectively. The effect of treatment in participants receiving nicergoline demonstrated significant coefficients (change in dB) in both ears (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.001). The mean different threshold of participants receiving nicergoline showed negative STS in all tested frequencies without statistical significance. However, the mean different threshold of participants receiving a placebo showed positive STS with statistical significance. Additionally, there were 16 ears detecting a warning sign of permanent hearing loss. These participants from the control group presented a longer duration of tinnitus (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.042). Moreover, the serious adverse effects of nicergoline were considerably low.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study results suggest that nicergoline may attenuate noise\u2010related TTS and tinnitus, and justify further investigation on the effectiveness of this drug as an otoprotectant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>2<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.746","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T07:48:04Z","timestamp":1643096884000},"page":"515-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A clinical trial of nicergoline to prevent temporary threshold shift"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2442-2481","authenticated-orcid":false,"given":"Pana","family":"Klamkam","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Phramongkutklao Hospital, Royal Thai Amy  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongrat","family":"Pagcharoenpol","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Phramongkutklao Hospital, Royal Thai Amy  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Treewit","family":"Treesaranuwattana","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Queen Sirikit Naval Hospital  Sattahip Chonburi Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pichayen","family":"Silpsrikul","sequence":"additional","affiliation":[{"name":"Medical Battalion, Support Regiment, Marines Division Royal Thai Navy  Sattahip Chonburi Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pariyanan","family":"Jaruchinda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Phramongkutklao Hospital, Royal Thai Amy  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyalarp","family":"Wasuwat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Phramongkutklao Hospital, Royal Thai Amy  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-0108","authenticated-orcid":false,"given":"Picha","family":"Suwannahitatorn","sequence":"additional","affiliation":[{"name":"Department of Parasitology Phramongkutklao College of Medicine  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2011.552427"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-017-0219-x"},{"key":"e_1_2_8_4_1","unstructured":"AffairsDoV.VBA annual benefits report fiscal year 2020.2020"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-015-0034-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001135"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814545325"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(86)90107-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986710792927895"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(01)00224-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(97)00010-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aud.0000191942.36672.f3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(94)90036-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.07.005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.01.002"},{"key":"e_1_2_8_16_1","unstructured":"CampbellKCM.Phase 2 Clinical Trials: D\u2010Methionine to Reduce Noise\u2010induced Hearing Loss. 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