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This study aims to survey the expression of circadian clock genes in peripheral blood (PB) leukocytes of MD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the expression of nine circadian clock genes in the PB leukocytes of patients with MD and normal controls using real\u2010time quantitative reverse transcriptase\u2010polymerase chain reaction (qRT\u2010PCR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed significantly lower expression of <jats:italic>PER1<\/jats:italic> gene and higher expression of <jats:italic>CLOCK<\/jats:italic> gene in MD patients than those in normal controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). <jats:italic>PER1<\/jats:italic> did not associate with the degree of dizziness handicap in the patients with MD, but a lower expression of <jats:italic>PER1<\/jats:italic> was significantly correlated with higher pure tone average (PTA) and speech reception threshold of the affected ear (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Patients with PTA\u2009&gt;\u200930\u2009dB had significantly lower <jats:italic>PER1<\/jats:italic> expression than those with PTA \u226430\u2009dB in the affected ear (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Our qRT\u2010PCR result was validated by fewer positively stained leukocytes for PER1 protein in the MD patients using the immunocytochemical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study implies the alteration of the circadian clock in patients with MD. In particular, the downregulation of <jats:italic>PER1<\/jats:italic> correlated with the degree of hearing loss in the affected ear. <jats:italic>PER1<\/jats:italic> in PB leukocytes may be a potential marker for the progression of hearing loss in MD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.757","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T10:44:37Z","timestamp":1645181077000},"page":"584-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Expression of circadian clock genes in leukocytes of patients with Meniere's disease"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4055-1686","authenticated-orcid":false,"given":"Chao\u2010Hui","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung 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