{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:30:45Z","timestamp":1789122645911,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970853"],"award-info":[{"award-number":["81970853"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873691"],"award-info":[{"award-number":["81873691"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970854"],"award-info":[{"award-number":["81970854"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High tissue and blood eosinophils are linked to poor treatment outcome in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). However, the difference between the patients with different level of blood or tissue eosinophilia in relation to disease control is still lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to characterize patients with CRSwNP with intensely high eosinophil level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of CRSwNP patients underwent endoscopic sinus surgery was conducted. The patients were subdivided with various cut\u2010off values of blood and tissue eosinophils. Tissue eosinophils of \u226550% and 10%\u201320% were defined as intensely high tissue eosinophils (IH\u2010tissue\u2010eos) and high tissue eosinophils (H\u2010tissue\u2010eos), respectively. Blood eosinophils of \u22650.6\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L and 0.2\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L\u20130.3\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L were defined as intensely high blood eosinophils (IH\u2010blood\u2010eos) and high blood eosinophils (H\u2010blood\u2010eos). Clinical characteristics, Lund\u2010Mackay score (LMS), and disease control status were compared between subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 302 patients were enrolled. There was a trend toward a higher rate of uncontrolled disease when the patients subdivided by blood eosinophil cut\u2010off values ranged from 0.1\u00a0\u00d7\u200910<jats:sup>9<\/jats:sup>\/L to 0.6\u00a0\u00d7\u200910<jats:sup>9<\/jats:sup>\/L. The controlled patients accounted for 27%, 36%, 22%, and 31%, and the uncontrolled patients 46%, 32%, 52%, and 31% of patients in IH\u2010tissue\u2010eos, H\u2010tissue\u2010eos, IH\u2010blood\u2010eos, and H\u2010blood\u2010eos subgroup, respectively. The percentages of patients in the three categories of control were not significantly different between IH\u2010tissue\u2010eos and H\u2010tissue\u2010eos subgroups. By contrast, the IH\u2010blood\u2010eos subgroup had higher percentages of current smoker and asthma, preoperative LMS and tissue eosinophil percentage, and showed a trend toward a higher rate of uncontrolled subjects compare with the H\u2010blood\u2010eos subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CRSwNP patients with IH\u2010blood\u2010eos (\u22650.6\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L) may be possibly associated with a poorer disease control than those with levels near the threshold of blood eosinophilia (0.2\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L\u20130.3\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L). Further larger, preferably prospective studies are needed to confirm this relationship.<\/jats:p><jats:p>Level of Evidence: 4.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.758","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T12:32:52Z","timestamp":1644841972000},"page":"316-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical characteristics of patients with CRSwNP with intensely high eosinophil level"],"prefix":"10.1002","volume":"7","author":[{"given":"Ling","family":"Ma","sequence":"first","affiliation":[{"name":"Jinan University  Guangzhou China"},{"name":"Department of Otorhinolaryngology The University of Hong Kong\u2010Shenzhen Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanghua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2382-0429","authenticated-orcid":false,"given":"Yueqi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The Seventh Affiliated Hospital of Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou 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