{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:54:11Z","timestamp":1778601251675,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870711"],"award-info":[{"award-number":["81870711"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2020JJ4791"],"award-info":[{"award-number":["2020JJ4791"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with obstructive sleep apnea (OSA) are more likely to suffer from hypertension. At the same time, the serum levels of matrix metalloproteinase\u20109 (MMP\u20109) and nitric oxide (NO) in patients with OSA are also changed in OSA patients. We investigated the correlation between serum levels of MMP\u20109, NO in patients with OSA and their association with hypertension in those patients, and the effects of continuous positive airway pressure therapy (CPAP) on these serum biomarkers and blood pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum MMP\u20109 and NO levels and blood pressure of 57 patients with newly diagnosed OSA and 30 controls were measured; among them, 30 patients with moderate to severe OSA underwent 3\u2010month CPAP treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison to the control group, the MMP\u20109 serum levels were higher (232.8\u2009\u00b1\u2009103.2\u00a0ng\/ml versus 161.6\u2009\u00b1\u200956.5\u00a0ng\/ml, <jats:italic>p<\/jats:italic> &lt; .001*), there was no statistical significance difference among serum NO (26.7\u2009\u00b1\u20099.1 IU\/ml versus 31.0\u2009\u00b1\u200911.7 IU\/ml, <jats:italic>p<\/jats:italic> = .06), and MMP\u20109 was negatively correlated to NO, especially in\u00a0patients with hypertension (<jats:italic>r<\/jats:italic> = \u2212.644, <jats:italic>p<\/jats:italic> = .02*). MMP\u20109, NO, and blood pressure were significantly recovered in the patients with OSA after CPAP treatment for 3 months (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05*).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The MMP\u20109 level and the NO level were altered in OSA patients. The relationship between the two especially in patients with hypertension suggests the potential mechanism of OSA\u2010induced hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.796","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T12:34:31Z","timestamp":1650890071000},"page":"885-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of matrix metalloproteinase\u20109 and nitric oxide with hypertension in obstructive sleep apnea"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6609-5175","authenticated-orcid":false,"given":"Shiying","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital Central South University  Changsha Hunan 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