{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:24:59Z","timestamp":1780572299276,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2019YFS0207"],"award-info":[{"award-number":["2019YFS0207"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2020YFS0113"],"award-info":[{"award-number":["2020YFS0113"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802468"],"award-info":[{"award-number":["81802468"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was to compare tonsillectomy with intraoperative suturing (TIS) and tonsillectomy without intraoperative suturing (TsIS) in preventing postoperative tonsillectomy hemorrhage (PTH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) guidelines was followed. Articles compare TIS and TsIS in preventing PTH were included. The quality of eligible studies was assessed with the Newcastle\u2010Ottawa Scale (NOS) by two independent investigators. Random effect models were used to determine odds ratio (OR) with 95% CIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15 studies were analyzed. The pooled results showed the PTH rate was lower in the TIS group (OR\u00a0=\u00a00.64; 95% CI, 0.47\u20130.88). The TIS group had a lower primary and secondary PTH rate than the TsIS group with OR values of 0.44 (95% CI, 0.30\u20130.64) and 0.70 (95% CI, 0.54\u20130.90), respectively. However, suturing did not show an advantage in reducing the risk of returning to the operation room for hemostasis (OR\u00a0=\u00a00.57; 95% CI, 0.13\u20132.47). Adults might benefit from the intraoperative suturing procedure (OR\u00a0=\u00a00.31; 95% CI, 0.16\u20130.60). Patients with more than three stitches on each side had a lower PTH rate (OR: 0.44; 95% CI, 0.32\u20130.60). Suturing the tonsillar fossa and pillars simultaneously could reduce the PTH rate (OR\u00a0=\u00a00.47; 95% CI, 0.34\u20130.64).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intraoperative suturing is a good strategy for preventing PTH. More multicenter randomized controlled studies should be conducted to demonstrate the efficacy of this procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>5.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.835","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T07:39:43Z","timestamp":1655969983000},"page":"1206-1216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Can intraoperative suturing reduce the incidence of posttonsillectomy hemorrhage? A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-2550","authenticated-orcid":false,"given":"Bo","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head &amp; Neck Surgery, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaowei","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Rehabilitation, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Wang","sequence":"additional","affiliation":[{"name":"West China Medical School Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center of Infectious Diseases, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599810389949"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/mlg.0b013e318031f0b0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.02.021"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22347"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12361"},{"key":"e_1_2_10_7_1","unstructured":"WellsGA SheaB O'ConnellD et al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta\u2010analyses.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100099199"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1995.tb00028.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.12.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700110"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4197\/Med.16-3.6"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.09.004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047874"},{"issue":"10","key":"e_1_2_10_15_1","first-page":"2573","article-title":"Can pillar suturing promote efficacy of adenotonsillectomy for pediatric OSAS?","volume":"123","author":"Chiu PH","year":"2013","journal-title":"A Prospective Randomized Controlled Trial Laryngoscope"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3075-6"},{"key":"e_1_2_10_17_1","first-page":"108","article-title":"Modified surgical technique with pillars repair in reducing post tonsillectomy haemorrhage","volume":"3","author":"Elkholy TA","year":"2016","journal-title":"Int Inv J Med Med Sci"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000003827"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131709600702"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5148-4"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13129"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.0487"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2017.08.012"},{"issue":"5","key":"e_1_2_10_24_1","first-page":"316","article-title":"Postoperative characteristics of combined pharyngoplasty and tonsillectomy versus tonsillectomy in children with obstructive sleep apnea syndrome","volume":"116","author":"Shu Y","year":"2018","journal-title":"Arch Argent Pediatr"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102632"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102760"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3025-3"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215119000434"},{"issue":"8","key":"e_1_2_10_29_1","article-title":"Coblation versus other surgical techniques for tonsillectomy","volume":"8","author":"Pynnonen M","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_30_1","unstructured":"Royal College of Surgeons of England.2005.National prospective tonsillectomy audit: Final report of an audit carried out in England and Northern Ireland between July 2003 and September 2004.http:\/\/www.entuk.org\/members\/audits\/tonsil\/Tonsillectomyauditreport_pdf."},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.12.003"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215117000755"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2018.08.027"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e3182948f26"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-199012000-00014"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.5.6.488"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2019.12.007"}],"container-title":["Laryngoscope Investigative Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lio2.835","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lio2.835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T05:29:32Z","timestamp":1726205372000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lio2.835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,23]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/lio2.835"],"URL":"https:\/\/doi.org\/10.1002\/lio2.835","archive":["Portico"],"relation":{},"ISSN":["2378-8038","2378-8038"],"issn-type":[{"value":"2378-8038","type":"print"},{"value":"2378-8038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,23]]},"assertion":[{"value":"2022-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}