{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:54:41Z","timestamp":1788537281813,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005421","name":"Guilan University of Medical Sciences","doi-asserted-by":"publisher","award":["2263"],"award-info":[{"award-number":["2263"]}],"id":[{"id":"10.13039\/501100005421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to evaluate the effect of local nasal desmopressin premedication on blood loss and the quality of surgical field in Functional Endoscopic Sinus Surgery (FESS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In a randomized clinical trial, patients referred for FESS to treat their bilateral chronic rhinosinusitis were recruited. The participants were adults (\u226518\u2009years). They were randomly assigned (1:1:1) to receive low\u2010dose (20\u2009\u03bcg) or high\u2010dose (40\u2009\u03bcg) intranasal desmopressin (DDAVP) or placebo 60\u2009min before the induction of general anesthesia. Standard FESS was performed by the same surgeon. The primary outcomes were volume of intraoperative bleeding and the quality of surgical field. Clean surgical field was defined as a score\u2009\u22642 on the Boezaart grading system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 120 patients were included on an intention\u2010to\u2010treat basis (mean age: 41.0\u2009years; 40 women, 80 men). There were no significant differences in primary outcomes between low\u2010dose DDAVP and placebo. As for the volume of blood loss, however, there was a significant difference between high\u2010dose DDAVP and placebo (mean difference: 29.6\u00a0ml; adjusted Cohen's d: \u22121.02; <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001). Also, in the high\u2010dose DDAVP, the probability of having a good surgical field over time was about two times higher than in the placebo group (RRs for first and second surgical sides: 1.89 and 2.18). The number needed to treat for the two time points was 1.6 and 1.3, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study showed that the use of desmopressin at a dose of 40\u2009\u03bcg 1\u00a0h before surgery can reduce bleeding and improve the quality of the surgical field. Further studies are recommended to be able to generalize these findings to other ENT surgeries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>1b.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.841","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T11:00:07Z","timestamp":1656068407000},"page":"920-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of desmopressin on bleeding during endoscopic sinus surgery: A randomized clinical trial"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1352-9814","authenticated-orcid":false,"given":"Maliheh","family":"Akbarpour","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Research Center, School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-7070","authenticated-orcid":false,"given":"Mir Mohammad","family":"Jalali","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Research Center, School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9036-9674","authenticated-orcid":false,"given":"Maryam","family":"Akbari","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Research Center, School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soudabeh","family":"Haddadi","sequence":"additional","affiliation":[{"name":"Anesthesiology Research Center, Department of Anesthesiology, Alzahra Hospital Guilan University of Medical Sciences  Rasht 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sinus surgery (Fess)","volume":"16","author":"Bajpai S","year":"2017","journal-title":"IOSR J Dent Sci"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900313"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.174"},{"key":"e_1_2_8_7_1","volume-title":"Endoscopic sinus surgery\u2010anatomy, three\u2010dimensional reconstruction, and surgical technique","author":"Wormald P","year":"2018"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095\u2010019\u20102628\u20101"},{"key":"e_1_2_8_9_1","unstructured":"PDR.net Web site.Drug summary: desmopressin acetate.https:\/\/www.pdr.net\/drug-summary\/DDAVP-Nasal-Spray-desmopressin-acetate-1034.4562 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