{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:41:14Z","timestamp":1764175274987,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The role of neurogenic inflammation in pathogenesis of chronic rhinitis is well known. However, very little is known about its importance in pathogenesis of nasal polyposis (NP), especially in form of NP which appears as a part of aspirin\u2010exacerbated respiratory disease (AERD). The aim of this study was to examine the concentrations of neuropeptides substance P (SP) and bradykinin (BK) in nasal secretions of patients with NP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen patients with NP as a part of AERD with mild persistent asthma, 14 patients with NP without aspirin sensitivity, and 14 control subjects without nasal inflammation (C) entered this cross\u2010sectional study. Clinical parameters (symptoms, endoscopic, and radiological findings) were assessed. The concentrations of SP and BK were measured in the nasal secretion samples using commercial human enzyme immunoassay kits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The concentration of SP in nasal secretions was significantly higher in NP patients without aspirin sensitivity and AERD patients compared to controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.022; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001, respectively), but higher in AERD than in non\u2010AERD patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.018). The level of BK in nasal fluid was higher in non\u2010AERD and AERD NP patients than in controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001, respectively), but also higher in AERD than in non\u2010AERD patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). We found high positive correlations between BK in nasal fluid and Lund\u2013Mackay computed tomography (CT) score in both non\u2010AERD and AERD groups of NP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest more intense release of SP and BK from the nasal mucosa in patients with AERD than in patients with NP who do not have aspirin sensitivity. The strong correlation between concentration of BK in nasal secretions and CT score suggests that BK in nasal fluid could be used as a marker for disease severity as measured by the Lund\u2013Mackay score.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.851","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T05:39:55Z","timestamp":1656567595000},"page":"928-934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of substance P and bradykinin levels in nasal secretions of patients with nasal polyposis with and without sensitivity to non\u2010steroidal anti\u2010inflammatory drugs"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8453-7272","authenticated-orcid":false,"given":"Aleksandar","family":"Peri\u0107","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine of the Military Medical Academy 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