{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:33:02Z","timestamp":1764333182683,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["22733"],"award-info":[{"award-number":["22733"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Hypothyroidism has a significant effect on the patients' voices. This study evaluated the histopathological characteristics of larynx following hypothyroidism in an experimental rabbit model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven male Dutch rabbits were included. Methimazole\u2010induced hypothyroidism was done for nine rabbits. The remaining two rabbits were assigned as controls. Six weeks after starting methimazole, a histological examination was performed with parameters of inflammation, ulceration, hemorrhage, and thickness of epithelium, Reinke's space, vocal ligament, thyroarytenoid muscle, collagen deposition, and periodic acid\u2010Schiff (PAS)\u2010positive materials, as well as confirmation of hypothyroidism by T4 measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histologic examination showed a significant thickening of epithelium, Reinke's space, vocal ligament, and collagen PAS\u2010positive materials deposition in hypothyroid rabbits (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.05). There was significant reduction in thyroarytenid muscle thickness (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.05). Inflammation, ulceration, and bleeding were not significantly different between hypothyroid and control rabbits' laryngeal specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hypothyroidism causes significant changes in the laryngeal tissues. Thickening of epithelium, Reinke's space, vocal ligament, collagen, PAS\u2010positive materials, and reduced thickness of thyroarytenoid muscle are the major findings of this study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.852","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T14:23:50Z","timestamp":1656771830000},"page":"1051-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Histopathological characteristics of larynx in hypothyroidism in an experimental rabbit model"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8302-2683","authenticated-orcid":false,"given":"Kamyar","family":"Iravani","sequence":"first","affiliation":[{"name":"Otolaryngology Research Center, Department of Otolaryngology Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnaz","family":"Golkhar","sequence":"additional","affiliation":[{"name":"Otolaryngology Research Center, Department of Otolaryngology Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negar","family":"Azarpira","sequence":"additional","affiliation":[{"name":"Transplant Research Center Shiraz Institute of Stem Cell and Regenerative Medicine, Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Kohandel\u2010Shirazi","sequence":"additional","affiliation":[{"name":"Department of Pathology Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahjoob","family":"Vahedi","sequence":"additional","affiliation":[{"name":"Center of Comparative and Experimental Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30703-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2021.09.003"},{"issue":"2","key":"e_1_2_8_4_1","first-page":"101","article-title":"Voice characteristics in patients with thyroid disorders. 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