{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:50:18Z","timestamp":1787169018130,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Remifentanil is usually used for controlled hypotension during rhinoplasty under general anesthesia (G\/A). One of the complications of the remifentanil is postoperative hyperalgesia. In this study, we compare the effectiveness of pregabalin with that of Mg sulfate in postoperative remifentanil\u2010induced hyperalgesia prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, randomized, double\u2010blinded placebo\u2010controlled trial, 105 patients who candidates rhinoplasty with G\/A were enrolled and randomly allocated into three groups. Patients in group A received 300\u2009mg pregabalin before anesthesia. They received physiologic saline infusion during the perioperative period. Those in group B received placebo capsules before anesthesia and intravenous Mg sulfate 30\u2009mg\/kg during the perioperative period. Those in group C received a placebo capsule before anesthesia and normal intravenous saline during the operation. Then, pain severity, sedation score, postoperative nausea and vomiting (PONV) were assessed and compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the Mg sulfate and placebo group, the mean numerical rating scale in the postoperative period was higher compared to the pregabalin group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). The mean total amount of morphine requirement, meanwhile the 24\u2009h post\u2010operation, was significantly decreased in the pregabalin group compared to the other groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Participants in the pregabalin group had less PONV compared to those in the pregabalin and placebo groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients undergoing G\/A with remifentanil for rhinoplasty, preoperative 300\u2009mg pregabalin could effectively prevent not only remifentanil\u2010induced hyperalgesia but also PONV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence<\/jats:title>\n                    <jats:p>1b.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lio2.905","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T09:58:05Z","timestamp":1661335085000},"page":"1360-1366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of pregabalin with magnesium sulfate in the prevention of remifentanil\u2010induced hyperalgesia in patients undergoing rhinoplasty: A randomized clinical trial"],"prefix":"10.1002","volume":"7","author":[{"given":"Seyed Mohammad Reza","family":"Hadavi","sequence":"first","affiliation":[{"name":"Shiraz Anesthesiology and Intensive Care Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Eghbal","sequence":"additional","affiliation":[{"name":"Shiraz Anesthesiology and Intensive Care Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Kaboodkhani","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Shiraz Anesthesiology and Intensive Care Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1510-0103","authenticated-orcid":false,"given":"Mohammad Ali","family":"Sahmeddini","sequence":"additional","affiliation":[{"name":"Shiraz Anesthesiology and Intensive Care Research Center Shiraz University of Medical Sciences  Shiraz 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